Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome 00185, Italy.
Department of Economics & Finance, University of Rome "Tor Vergata", Rome 00185, Italy.
World J Gastroenterol. 2019 Dec 28;25(48):6928-6938. doi: 10.3748/wjg.v25.i48.6928.
Alterations in health-related quality of life (HRQoL) and neuropsychological disorders were described in the hepatitis C virus (HCV) patients. Although several studies investigated the modifications of HRQoL after HCV eradication, no data exists on the modifications of neuropsychological symptoms.
To investigate the effect of directly acting antivirals (DAAs) treatment on HRQoL and neuropsychological symptoms.
Thirty nine patients with HCV infection underwent a neuropsychological assessment, including Zung-Self Depression-Rating-Scale, Spielberg State-Trait Anxiety Inventory Y1-Y2 and the Toronto-Alexithymia Scale-20 items before and after DAAs treatment. HRQoL was detected by Short-Form-36 (SF-36).
All HRQoL domains, but role limitation physical and bodily pain, significantly improved after treatment. Interestingly, after DAAs treatment, all domains of HRQoL returned similar to those of controls. Each neuropsychological test significantly improved after HCV eradication. A significant correlation was observed among each psychological test and the summary components of SF-36. At multiple linear regression analysis including each psychological test as possible covariates, Zung-Self Depression Rating Scale (Zung-SDS) score was independently and significantly related to summary components of the SF-36 in the basal state and the difference between Zung-SDS score before and after treatment was the only variable significantly and independently related to the modification of HRQoL induced by the treatment.
Neuropsychological symptoms strongly influenced HRQoL in HCV patients and there was a significant improvement of neuropsychological tests and HRQoL after DAAs treatment.
丙型肝炎病毒 (HCV) 感染者的健康相关生活质量 (HRQoL) 和神经认知障碍会发生改变。虽然有几项研究调查了 HCV 清除后 HRQoL 的变化，但关于神经认知症状变化的数据尚不存在。
研究直接作用抗病毒药物 (DAA) 治疗对 HRQoL 和神经认知症状的影响。
39 例 HCV 感染患者在 DAA 治疗前后接受了神经心理学评估，包括 Zung 自评抑郁量表、Spielberg 状态特质焦虑问卷 Y1-Y2 和多伦多述情障碍量表-20 项。HRQoL 通过简明健康量表 36 项（SF-36）进行检测。
所有 HRQoL 领域（身体角色受限和身体疼痛除外）在治疗后均显著改善。有趣的是，在 DAA 治疗后，HRQoL 的所有领域均恢复到接近对照组的水平。所有神经心理学测试在 HCV 清除后均显著改善。各心理测试与 SF-36 的综合成分之间存在显著相关性。在包括每个心理测试作为可能协变量的多元线性回归分析中，Zung 自评抑郁量表 (Zung-SDS) 评分在基础状态和治疗前后 Zung-SDS 评分差值与 SF-36 综合成分之间呈独立且显著相关，是唯一与治疗引起的 HRQoL 变化显著相关的变量。
神经认知症状强烈影响 HCV 患者的 HRQoL，DAA 治疗后神经认知测试和 HRQoL 显著改善。
