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乳腺癌患者仅骨转移的放射治疗:GOCO对当前临床实践的调查。

Radiation therapy for bone-only metastases in breast cancer patients: A GOCO survey of current clinical practice.

作者信息

Bonet Marta, García Virginia, Farré Núria, Algara Manel, Farrús Blanca, Fernandez Jaume, Reyes Victoria, Eraso Arancha, Álvarez Ana, Cambra Maria José, Pedro Agustí, Vayreda Jordi, Lemansky Claire, Izar Françoise, Arenas Meritxell

机构信息

Department of Radiation Oncology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.

Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

出版信息

Rep Pract Oncol Radiother. 2020 Jan-Feb;25(1):113-116. doi: 10.1016/j.rpor.2019.12.019. Epub 2019 Dec 20.

DOI:10.1016/j.rpor.2019.12.019
PMID:31908604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6938868/
Abstract

INTRODUCTION

The role of radiation therapy (RT) for patients with bone-only metastatic (BOM) breast cancer has not been investigated sufficiently. The aim of this survey was to evaluate current clinical practice in treating breast cancer patients with BOM in Radiation Therapy Departments in Catalonia and Occitania within the scope of the GOCO group.

MATERIALS AND METHODS

An electronic questionnaire was completed by experienced radiation oncologists from fourteen RT centers. The items surveyed the professional experience, therapeutic approach, technique, dose stereotactic body RT (SBRT) availability.

RESULTS

All Radiation Oncology Departments (ROD) in Catalonia (12) and Occitania (2) responded to the survey. Eleven (78.5%) of the RODs advise RT for BOM as initial treatment in the oligometastatic setting. RT to asymptomatic bone oligometastases is more often restricted for "risky lesions". The most inconsistent approaches were the treatment for asymptomatic lesions, when to treat bone metastases with respect to systemic treatment (ST) and the indication for RT after a complete response to ST.

CONCLUSION

While BOM breast cancer patients have a relatively good prognosis, there is a lack of consistency in their approach with RT. This can be explained by the absence of evidence-based guidelines and an incomplete availability of SBRT.

摘要

引言

放射治疗(RT)在仅发生骨转移(BOM)的乳腺癌患者中的作用尚未得到充分研究。本次调查的目的是评估加泰罗尼亚和奥克西塔尼亚地区放射治疗科在GOCO组范围内治疗BOM乳腺癌患者的当前临床实践。

材料与方法

一份电子问卷由来自14个放疗中心的经验丰富的放射肿瘤学家填写。问卷项目调查了专业经验、治疗方法、技术、立体定向体部放疗(SBRT)的剂量可用性。

结果

加泰罗尼亚的所有放射肿瘤学部门(ROD)(12个)和奥克西塔尼亚的(2个)都对调查做出了回应。11个(78.5%)ROD建议将RT作为寡转移情况下BOM的初始治疗方法。对无症状骨寡转移灶进行放疗更多地局限于“高危病变”。最不一致的方法是对无症状病变的治疗、在全身治疗(ST)方面何时治疗骨转移以及ST完全缓解后RT的指征。

结论

虽然BOM乳腺癌患者预后相对较好,但在RT治疗方法上缺乏一致性。这可以用缺乏循证指南以及SBRT可用性不完整来解释。

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Emerging Opportunities of Radiotherapy Combined With Immunotherapy in the Era of Breast Cancer Heterogeneity.乳腺癌异质性时代放疗联合免疫治疗的新机遇
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