Hoffmann Daniel Bernd, Popescu Christian, Komrakova Marina, Welte Lena, Saul Dominik, Lehmann Wolfgang, Hawellek Thelonius, Beil Frank Timo, Dakna Mohammed, Sehmisch Stephan
Department of Trauma-, Orthopaedic- and Plastic Surgery, University Medical Center Goettingen, Goettingen, Germany.
Department of Medical Statistics, University Medical Center Goettingen, Goettingen, Germany.
Bone Rep. 2019 Dec 6;12:100234. doi: 10.1016/j.bonr.2019.100234. eCollection 2020 Jun.
We evaluated the prevalence and influence of chronic hyponatremia in patients with low energy trauma. We also investigated the influence of medication and diseases on hyponatremia.
This retrospective study included 314 cases of proximal femoral fracture due to low energy trauma. Patients were treated in the University Medical Center Goettingen within 3 years. Hyponatremia was defined as serum sodium <135 mmol/L at admission.
Overall, 15.6% of patients in the low energy trauma group had hyponatremia. Among patients older than 80 years, women showed distinctly higher rates of hyponatremia (female: 16.4%; male: 5.9%). In contrast only 4.7% of patients who underwent elective hip arthroplasty showed hyponatremia. Patients on sartanes and aldosterone antagonists showed significantly higher rates of hyponatremia. Alcoholism was significantly associated with hyponatremia.
We confirmed a high prevalence of chronic hyponatremia in patients with fractures due to low energy trauma. Our data underscore chronic hyponatremia as a contributing factor to hip fractures. Women older than 80 have a higher risk of developing hyponatremia. Sartanes, aldosterone antagonists, and alcohol disease are associated with hyponatremia. Treating hyponatremia may decrease the risk of fracture after low energy trauma. Therefore, physicians of different specialties should focus on treatment of chronic hyponatremia to reduce the fracture rate associated with low energy trauma.
我们评估了低能量创伤患者慢性低钠血症的患病率及其影响。我们还研究了药物和疾病对低钠血症的影响。
这项回顾性研究纳入了314例因低能量创伤导致的股骨近端骨折患者。这些患者在哥廷根大学医学中心接受了为期3年的治疗。低钠血症定义为入院时血清钠<135 mmol/L。
总体而言，低能量创伤组中15.6%的患者患有低钠血症。在80岁以上的患者中，女性低钠血症的发生率明显更高（女性：16.4%；男性：5.9%）。相比之下，接受择期髋关节置换术的患者中只有4.7%出现低钠血症。使用沙坦类药物和醛固酮拮抗剂的患者低钠血症发生率明显更高。酗酒与低钠血症显著相关。
我们证实了低能量创伤骨折患者中慢性低钠血症的高患病率。我们的数据强调慢性低钠血症是髋部骨折的一个促成因素。80岁以上的女性发生低钠血症的风险更高。沙坦类药物、醛固酮拮抗剂和酒精性疾病与低钠血症有关。治疗低钠血症可能会降低低能量创伤后骨折的风险。因此，不同专业的医生应关注慢性低钠血症的治疗，以降低与低能量创伤相关的骨折发生率。
