Rubio C A, Ost A, Larsson B
Department of Pathology, Karolinska Institute, Stockholm, Sweden.
APMIS. 1988 Oct;96(10):898-900. doi: 10.1111/j.1699-0463.1988.tb00958.x.
A large number of lymphocytes each surrounded by a clear halo were found in the foveolar epithelium of the fundic region and the antrum in a gastric biopsy from a patient with epigastric complaints. Electron microscopical studies demonstrated the presence of intraepithelial "in-halo" lymphocytes both underneath, between two contiguous, and within foveolar gastric cells. Normal numbers of lymphocytes (without haloes) were found in the lamina propria, suggesting that this epithelial lymphocytosis may be unrelated to "classical" chronic gastritis. The possibility of an autoimmune phenomenon at the foveolar cell level was discussed. The absence of intraepithelial lymphocytes in the glandular epithelium suggests that this phenomenon may be unrelated to the type of autoimmunity found in pernicious anaemia.
在一名有上腹部不适症状患者的胃活检标本中，发现胃底部区域和胃窦的小凹上皮中有大量淋巴细胞，每个淋巴细胞周围都有一个清晰的晕圈。电子显微镜研究表明，上皮内“晕圈内”淋巴细胞存在于相邻两个胃小凹细胞下方、之间以及胃小凹细胞内。在固有层中发现淋巴细胞数量正常（无晕圈），这表明这种上皮淋巴细胞增多可能与“经典”慢性胃炎无关。讨论了小凹细胞水平自身免疫现象的可能性。腺上皮中无上皮内淋巴细胞，这表明这种现象可能与恶性贫血中发现的自身免疫类型无关。
