低密度脂蛋白中硝化共轭亚油酸（NO-cLA）的检测与特性数据。
Data of detection and characterization of nitrated conjugated-linoleic acid (NO-cLA) in LDL.
作者信息
Mastrogiovanni Mauricio, Trostchansky Andres, Rubbo Homero
机构信息
Departamento de Bioquímica, Facultad de Medicina and Centro de Investigaciones Biomédicas (CEINBIO), Universidad de La República, Montevideo, Uruguay.
出版信息
Data Brief. 2019 Dec 20;28:105037. doi: 10.1016/j.dib.2019.105037. eCollection 2020 Feb.
Under physiological and pathophysiological conditions, lipid nitration occurs generating nitro-fatty acids (NFA) with pleiotropic activities as modulation of inflammatory cell responses. Foam cell formation and atherosclerotic lesion development have been extensively related to low-density lipoprotein (LDL) oxidation. Considering our manuscript "Fatty acid nitration in human low-density lipoprotein" (https://doi.org/10.1016/j.abb.2019.108190), herein we report the oxidation versus nitration of human LDL protein and lipid fractions. Data is shown on LDL fatty acid nitration, in particular, formation and quantitation of nitro-conjugated linoleic acid (NO-cLA) under mild nitration conditions. In parallel to NO-cLA formation, depletion of endogenous antioxidants, protein tyrosine nitration, and carbonyl formation is observed. Overall, our data propose the formation of a potential anti-atherogenic form of LDL carrying NFA.
在生理和病理生理条件下，会发生脂质硝化反应，生成具有多效活性的硝基脂肪酸（NFA），如对炎症细胞反应的调节。泡沫细胞形成和动脉粥样硬化病变发展与低密度脂蛋白（LDL）氧化密切相关。鉴于我们的论文《人低密度脂蛋白中的脂肪酸硝化》（https://doi.org/10.1016/j.abb.2019.108190），在此我们报告人LDL蛋白和脂质组分的氧化与硝化情况。展示了关于LDL脂肪酸硝化的数据，特别是在温和硝化条件下硝基共轭亚油酸（NO-cLA）的形成和定量。与NO-cLA形成同时，观察到内源性抗氧化剂的消耗、蛋白质酪氨酸硝化和羰基形成。总体而言，我们的数据表明形成了一种携带NFA的潜在抗动脉粥样硬化形式的LDL。
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