同时服用阿司匹林对替诺昔康血浆浓度的影响。
The effect of concurrent aspirin upon plasma concentrations of tenoxicam.
作者信息
Day R O, Paull P D, Lam S, Swanson B R, Williams K M, Wade D N
机构信息
Department of Clinical Pharmacology, St Vincent's Hospital, Sydney, N.S.W., Australia.
出版信息
Br J Clin Pharmacol. 1988 Oct;26(4):455-62. doi: 10.1111/j.1365-2125.1988.tb03405.x.
Abstract
- The effect of chronic, high-dose aspirin therapy upon the disposition of a single dose and multiple doses of tenoxicam was examined in normal volunteers. 2. Aspirin caused a 24% drop in the t1/2 (P less than 0.005), a 49% rise in the volume of distribution (P less than 0.0003) and a 98% increase in the clearance (P less than 0.0001) of tenoxicam after a single dose of the tenoxicam. 3. Steady-state concentrations of tenoxicam decreased significantly from 10.4 +/- 1.5 to 4.5 +/- 1.6 micrograms ml-1 in the presence of chronic, high-dose aspirin treatment. 4. Tenoxicam percentage free measured in plasma from a normal volunteer was 0.56 +/- 0.05% over the tenoxicam concentration range 1-20 micrograms ml-1 and rose to 1.24 +/- 0.07% in the presence of aspirin 150 micrograms ml-1. 5. The effect of aspirin upon the disposition of tenoxicam was consistent with a competitive protein binding interaction.
摘要
- 在正常志愿者中研究了长期大剂量阿司匹林治疗对单剂量和多剂量替诺昔康处置的影响。2. 单剂量替诺昔康给药后，阿司匹林使替诺昔康的半衰期下降24%（P<0.005），分布容积增加49%（P<0.0003），清除率提高98%（P<0.0001）。3. 在长期大剂量阿司匹林治疗情况下，替诺昔康的稳态浓度从10.4±1.5显著降至4.5±1.6微克/毫升。4. 一名正常志愿者血浆中替诺昔康的游离百分比在替诺昔康浓度范围1-20微克/毫升时为0.56±0.05%，在存在150微克/毫升阿司匹林时升至1.24±0.07%。5. 阿司匹林对替诺昔康处置的影响与竞争性蛋白结合相互作用一致。
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