Department of Chemical Engineering , Louisiana State University , Baton Rouge , Louisiana 70803 , United States.
J Am Chem Soc. 2020 Jan 29;142(4):1667-1672. doi: 10.1021/jacs.9b10156. Epub 2020 Jan 14.
DNA-mediated assembly of inorganic particles has demonstrated to be a powerful approach for preparing nanomaterials with a range of interesting optical and electrical properties. Building on this inspiration, we describe a generalizable gram-scale method to assemble nanoparticles through the formation of poly(methyl methacrylate) (PMMA) triple-helices. In this work, alkene-terminated (-) and (-) PMMA polymers were prepared and subsequently functionalized to afford nanoparticle ligands. Nanoparticles with complementary - and -PMMA ligands could then be spontaneously assembled upon mixing at room temperature. This process was robust and fully reversible through multiple heating and cooling cycles. The versatility of PMMA stereocomplexation was highlighted by assembling hybrid structures composed of nanoparticles of different compositions (e.g., Au and quantum dots) and shapes (e.g., spheres and rods). These initial demonstrations of nanoparticle self-assembly from inexpensive PMMA-based materials present an attractive alternative to DNA-based nanomaterials.
DNA 介导的无机颗粒组装已被证明是一种制备具有各种有趣的光学和电学性质的纳米材料的有力方法。受此启发，我们描述了一种可扩展的克级规模方法，通过形成聚甲基丙烯酸甲酯 (PMMA) 三螺旋来组装纳米颗粒。在这项工作中，制备了烯端 (-) 和 (-) PMMA 聚合物，然后对其进行官能化以提供纳米颗粒配体。具有互补 - 和 -PMMA 配体的纳米颗粒可以在室温下混合时自发组装。该过程通过多次加热和冷却循环具有很强的稳定性和完全的可逆性。PMMA 立构复合物的多功能性通过组装由不同组成（例如，金和量子点）和形状（例如，球体和棒体）的纳米颗粒组成的混合结构得到了突出体现。这些基于廉价 PMMA 材料的纳米颗粒自组装的初步演示为基于 DNA 的纳米材料提供了一种有吸引力的替代方案。
