Baltes B J
J Clin Pharmacol. 1977 Feb-Mar;17(2-3):120-4. doi: 10.1002/j.1552-4604.1977.tb04597.x.
A new analgesic compound, neopam HCl, was studied for possible gastrointestinal blood loss liabilities by Cr-51 red cell tagging. It was compared with aspirin in usual therapeutic doses of 1.8 Gm per day. Dosage of nefopam HCl was 180 mg per day (two tablets t.i.d). Twenty healthy male volunteers had fecal blood loss determined after one-week crossover periods of drug investigation, each preceded by one-week no-drug control periods. Results show a significant (P is less than 0.01) increase in occult bleeding in the aspirin-treated subjects from a mean of 0.5 ml to 1.63 ml per 24 hours, the mean increase for the group being 1.13 ml per 24 hours. Nefopam HCl treated subjects had an insignificant change from a control mean of 0.55 ml per 24 hours to 0.60 ml per 24 hours; a third of this group actually had a decrease in measurable blood loss. Reported side effects were minimal in both drug groups.
一种新的镇痛化合物盐酸奈福泮，通过铬-51红细胞标记法研究其可能导致胃肠道失血的倾向。将其与每天1.8克常规治疗剂量的阿司匹林进行比较。盐酸奈福泮的剂量为每天180毫克（每日三次，每次两片）。20名健康男性志愿者在为期一周的药物研究交叉期后测定粪便失血量，每个交叉期之前有一周的无药物对照期。结果显示，服用阿司匹林的受试者潜血出血量显著增加（P小于0.01），从平均每24小时0.5毫升增加到1.63毫升，该组平均每24小时增加1.13毫升。接受盐酸奈福泮治疗的受试者从每24小时对照平均值0.55毫升到0.60毫升的变化不显著；该组三分之一的受试者实际可测量失血量有所减少。两个药物组报告的副作用都很少。
