Presciuttini Silvano, Carli Giancarlo, Santarcangelo Enrica L
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Int J Clin Exp Hypn. 2020 Jan-Mar;68(1):29-37. doi: 10.1080/00207144.2020.1682254.
Fatty acid amide hydrolase (FAAH) degrades the endogenous endocannabinoid (eCB) anandamide and might be involved in the response to suggestions of analgesia in subjects with high hypnotizability scores (). Since the A allele of the FAAH C385A polymorphism (rs324420) is associated with lower FAAH activity, it was studied in 21 highs, 66 low hypnotizable individuals (), and 172 individuals not selected for hypnotizability () representing the general population. No significant difference was observed among groups, but the A allele frequency showed a significant trend to increase from lows to controls and from controls to highs. Since eCB small differences can be amplified by eCB interactions with other neurotransmitters, a contribution of the FAAH polymorphism to the highs' analgesia should not be excluded.
脂肪酸酰胺水解酶（FAAH）可降解内源性大麻素（eCB）花生四烯乙醇胺，并且可能参与高催眠易感性受试者对镇痛暗示的反应（）。由于FAAH C385A多态性（rs324420）的A等位基因与较低的FAAH活性相关，因此在21名高催眠易感性者、66名低催眠易感性个体（）以及172名未按催眠易感性选择的个体（）（代表一般人群）中进行了研究。各组之间未观察到显著差异，但A等位基因频率呈现出从低催眠易感性者到对照组以及从对照组到高催眠易感性者显著增加的趋势。由于eCB的微小差异可通过eCB与其他神经递质的相互作用而放大，因此不应排除FAAH多态性对高催眠易感性者镇痛作用的影响。
