[胆碱能过程在实现GABA阳性制剂镇痛作用中的作用]
[The role of cholinergic processes in realizing the analgesic effect of GABA-positive preparations].
作者信息
Ignatov Iu D, Andreev B V
出版信息
Farmakol Toksikol. 1988 Jul-Aug;51(4):29-31.
In experiments on male rats it was shown that scopolamine diminished while pilocarpine and physostigmine potentiated the antinociceptive effect of baclofen, gamma-acetylenic-GABA, THIP and depakine. At the same time the antinociceptive effect of pilocarpine virtually underwent no changes in baclofen- and depakine-tolerant animals. The results suggest that the cholinergic processes may be involved in GABAergic antinociception but not in the development of tolerance to the antinociceptive effect of GABA-positive drugs.
在对雄性大鼠的实验中发现，东莨菪碱会减弱巴氯芬、γ-乙炔基-GABA、THIP和丙戊酸的抗伤害感受作用，而毛果芸香碱和毒扁豆碱则会增强其抗伤害感受作用。同时，在对巴氯芬和丙戊酸产生耐受性的动物中，毛果芸香碱的抗伤害感受作用几乎没有变化。结果表明，胆碱能过程可能参与了GABA能抗伤害感受，但与对GABA阳性药物抗伤害感受作用的耐受性发展无关。
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