• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

乳腺癌患者孕期的肿瘤标志物值得信赖吗？一例妊娠晚期CA 15-3升高、产后恢复正常的病例。

Can we trust tumour markers in pregnancy after breast cancer? A case of elevated CA 15-3 in the third trimester of pregnancy normalising after delivery.

作者信息

Buonomo Barbara, Noli Stefania A, Santini Alessandra, Alviggi Carlo, Peccatori Fedro A

机构信息

Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy.

Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology IRCCS, 20141 Milan, Italy.

出版信息

Ecancermedicalscience. 2019 Nov 26;13:979. doi: 10.3332/ecancer.2019.979. eCollection 2019.

DOI:10.3332/ecancer.2019.979
PMID:31921350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6946420/
Abstract

We realized a narrative review of the current literature starting from the case of a patient with raised CA15-3 during an uncomplicated pregnancy after breast cancer. The aim of our paper was to assess specificity, physiological changes and clinical utility of CA 15-3 monitoring during pregnancy after breast cancer, starting from clinical practice and retrieving the most relevant evidence in the literature.

摘要

我们从一名乳腺癌后妊娠过程中CA15-3升高的患者病例入手，对当前文献进行了叙述性综述。我们论文的目的是从临床实践出发，检索文献中最相关的证据，评估乳腺癌后妊娠期间CA 15-3监测的特异性、生理变化及临床应用价值。

相似文献

1
Can we trust tumour markers in pregnancy after breast cancer? A case of elevated CA 15-3 in the third trimester of pregnancy normalising after delivery.乳腺癌患者孕期的肿瘤标志物值得信赖吗？一例妊娠晚期CA 15-3升高、产后恢复正常的病例。
Ecancermedicalscience. 2019 Nov 26;13:979. doi: 10.3332/ecancer.2019.979. eCollection 2019.
2
Tumour marker CA15-3: possible uses in the routine management of breast cancer.
Eur J Cancer. 1995 Jun;31A(6):899-902. doi: 10.1016/0959-8049(94)00447-1.
3
Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases.采用肿瘤标志物对乳腺癌患者进行强化术后随访：癌胚抗原（CEA）、组织多肽抗原（TPA）或糖类抗原15.3（CA15.3）与巨嗜细胞趋化蛋白（MCA）对比，以及MCA - CA15.3与CEA - TPA - CA15.3组合在远处转移早期检测中的应用
BMC Cancer. 2006 Nov 20;6:269. doi: 10.1186/1471-2407-6-269.
4
Elevated Levels of Serum Tumor Markers CEA and CA15-3 Are Prognostic Parameters for Different Molecular Subtypes of Breast Cancer.血清肿瘤标志物癌胚抗原（CEA）和糖类抗原15-3（CA15-3）水平升高是乳腺癌不同分子亚型的预后参数。
PLoS One. 2015 Jul 24;10(7):e0133830. doi: 10.1371/journal.pone.0133830. eCollection 2015.
5
Serum concentrations of CA 125, CA 15-3, CA 19-9 and CEA in normal pregnancy: a longitudinal study.正常妊娠时血清 CA125、CA15-3、CA19-9 和 CEA 浓度：一项纵向研究。
Arch Gynecol Obstet. 2012 Mar;285(3):579-84. doi: 10.1007/s00404-011-2025-4. Epub 2011 Jul 27.
6
Maternal serum Ca125 and Ca15-3 antigen levels in normal and pathological pregnancy.正常及病理妊娠时孕妇血清中Ca125和Ca15-3抗原水平
Fetal Diagn Ther. 2001 May-Jun;16(3):166-72. doi: 10.1159/000053903.
7
Obstetrical complications associated with abnormal maternal serum markers analytes.与母体血清标志物分析物异常相关的产科并发症。
J Obstet Gynaecol Can. 2008 Oct;30(10):918-932. doi: 10.1016/S1701-2163(16)32973-5.
8
Evaluation of serum CA27.29, CA15-3 and CEA in patients with breast cancer.乳腺癌患者血清CA27.29、CA15 - 3和癌胚抗原的评估
Kaohsiung J Med Sci. 1999 Sep;15(9):520-8.
9
A cross-sectional study of tumor markers during normal and high-risk pregnancies.正常妊娠和高危妊娠期间肿瘤标志物的横断面研究。
Int J Gynaecol Obstet. 2015 Jun;129(3):203-6. doi: 10.1016/j.ijgo.2014.12.014. Epub 2015 Mar 13.
10
The objective measurement of remission and progression in metastatic breast cancer by use of serum tumour markers. European Group for Serum Tumour Markers in Breast Cancer.利用血清肿瘤标志物客观测量转移性乳腺癌的缓解和进展情况。欧洲乳腺癌血清肿瘤标志物研究小组。
Eur J Cancer. 1999 Jan;35(1):47-53. doi: 10.1016/s0959-8049(98)00297-4.

引用本文的文献

1
Elevation of cancer antigen 15-3 owing to oncocytic renal neoplasm in a patient without evidence of breast cancer recurrence on follow-up: a case report.由于随访中无乳腺癌复发证据的嗜酸性肾肿瘤导致癌抗原 15-3 升高：病例报告。
J Med Case Rep. 2023 Dec 7;17(1):526. doi: 10.1186/s13256-023-04088-5.
2
Cancer and Pregnancy in the Post-Roe v. Wade Era: A Comprehensive Review.后罗诉韦德时代的癌症与妊娠：全面综述。
Curr Oncol. 2023 Oct 25;30(11):9448-9457. doi: 10.3390/curroncol30110684.

本文引用的文献

1
Cross-reactivity between MUC1 antigen and MCA: false elevation of serum CA 15-3 level in pregnant and lactating women by Ma695-Ma552-based assay.MUC1 抗原与 MCA 的交叉反应：基于 Ma695-Ma552 的检测方法导致孕妇和哺乳期妇女血清 CA 15-3 水平的假性升高。
Breast Cancer Res Treat. 2018 Jun;169(2):341-347. doi: 10.1007/s10549-018-4700-7. Epub 2018 Feb 2.
2
Cancer and fertility preservation: international recommendations from an expert meeting.癌症与生育力保存：专家会议的国际建议
BMC Med. 2016 Jan 4;14:1. doi: 10.1186/s12916-015-0545-7.
3
A cross-sectional study of tumor markers during normal and high-risk pregnancies.正常妊娠和高危妊娠期间肿瘤标志物的横断面研究。
Int J Gynaecol Obstet. 2015 Jun;129(3):203-6. doi: 10.1016/j.ijgo.2014.12.014. Epub 2015 Mar 13.
4
Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review.妊娠相关妇科恶性肿瘤患者血清肿瘤标志物的生理变化：系统综述。
BMC Med. 2012 Aug 8;10:86. doi: 10.1186/1741-7015-10-86.
5
Maternal serum CA 19-9 and CA 15-3 levels in pregnancies affected by trisomy 21.母体血清 CA 19-9 和 CA 15-3 水平在 21 三体综合征受影响的妊娠中。
Prenat Diagn. 2012 Jul;32(7):644-8. doi: 10.1002/pd.3875.
6
Serum concentrations of CA 125, CA 15-3, CA 19-9 and CEA in normal pregnancy: a longitudinal study.正常妊娠时血清 CA125、CA15-3、CA19-9 和 CEA 浓度：一项纵向研究。
Arch Gynecol Obstet. 2012 Mar;285(3):579-84. doi: 10.1007/s00404-011-2025-4. Epub 2011 Jul 27.
7
Tumor markers in biological fluids associated with pregnancy.与妊娠相关的生物体液中的肿瘤标志物。
Crit Rev Clin Lab Sci. 2007;44(2):151-78. doi: 10.1080/10408360601003143.
8
Maternal serum and umbilical cord tumor marker levels at term pregnancy.
Acta Obstet Gynecol Scand. 2005 Jan;84(1):85-9. doi: 10.1111/j.0001-6349.2005.00584.x.
9
Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing.女性癌症幸存者的生育力：病理生理学、生育力保存及卵巢储备功能检测的作用
Hum Reprod Update. 2005 Jan-Feb;11(1):69-89. doi: 10.1093/humupd/dmh052. Epub 2004 Nov 29.
10
High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer.术前高CA 15-3浓度预示淋巴结阴性和阳性乳腺癌患者预后不良：对600例经组织学确诊的乳腺癌患者的研究。
Clin Chem. 2004 Mar;50(3):559-63. doi: 10.1373/clinchem.2003.025288. Epub 2004 Jan 15.