脂磷壁酸可降低H9c2细胞中的抗氧化酶水平。

Lipoteichoic acid reduces antioxidant enzymes in H9c2 cells.

作者信息

Fernández-Rojas Berenice, Vázquez-Cervantes Gustavo I, Pedraza-Chaverri José, Gutiérrez-Venegas Gloria

机构信息

Laboratorio de Bioquímica de la División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 Ciudad de México, México.

Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Circuito interior s/n, Ciudad Universitaria, 04510, Ciudad de México, México.

出版信息

Toxicol Rep. 2019 Dec 30;7:101-108. doi: 10.1016/j.toxrep.2019.12.007. eCollection 2020.

Infective endocarditis (IE) is an illness where the heart is invaded by bacteria, like and species that contain lipoteichoic acid (LTA) related to an essential role in this disease. This study is the first in evaluating antioxidant enzyme levels in embryonic cardiomyocyte cell line (H9c2) induced by LTA from . LTA increased reactive oxygen species (ROS) and reduced the levels of the antioxidant enzymes glutathione peroxidase, superoxide dismutase (SOD)-1 and catalase (CAT) but did not affect glutathione content. At the highest LTA concentration (15 μg/ml), SOD-1 and CAT levels did not change, and this effect was related to the induction of mRNA levels of Nrf2 induced by LTA. These results suggest that low antioxidant enzyme levels and ROS production could be related to IE.

感染性心内膜炎（IE）是一种心脏被细菌侵袭的疾病，如含有与该疾病重要作用相关的脂磷壁酸（LTA）的[具体细菌名称1]和[具体细菌名称2]等菌种。本研究首次评估了由[具体细菌名称3]的LTA诱导的胚胎心肌细胞系（H9c2）中抗氧化酶水平。LTA增加了活性氧（ROS）并降低了抗氧化酶谷胱甘肽过氧化物酶、超氧化物歧化酶（SOD）-1和过氧化氢酶（CAT）的水平，但不影响谷胱甘肽含量。在最高LTA浓度（15μg/ml）时，SOD-1和CAT水平没有变化，这种效应与LTA诱导的Nrf2 mRNA水平的升高有关。这些结果表明，低抗氧化酶水平和ROS产生可能与IE有关。