Ma Guangzhi, Deng Yunfu, Chen Wenjie, Liu Zhenkun, Ai Cheng, Li Xuebing, Zhou Qinghua
Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Front Oncol. 2019 Dec 20;9:1441. doi: 10.3389/fonc.2019.01441. eCollection 2019.
MET protein expression has been reported to be in relevance with the survival of NSCLC patients in various studies, yet the results were inconsistent. The purpose of our study set out to determine the prognostic role of both c-MET and p-MET expression among NSCLC that underwent surgical resection. Data were obtained from retrospective cohort studies by searching on PubMed, Cochrane Library, EMBASE and Web of Science, and a meta-analysis was performed to assess the prognostic role of MET expression among NSCLC. Totally 18 literatures including 5,572 surgically resected NSCLC cases staged I-IV were included for data synthesis. The positive rate of c-MET and p-MET was 1,753/4,315 and 135/1,257. The pooled hazard ratios (HRs) regarding c-MET and p-MET expression for overall survival (OS) was 1.623 (95% CI: 1.176-2.240, = 0.003) and 1.710 (95% CI: 0.823-3.533, = 0.15), respectively. Subgroup analysis results on Asian (HR = 2.115, < 0.001), adenocarcinoma (HR = 2.220, < 0.001) and rabbit polyclonal antibodies (HR = 2.107, < 0.001) etc. were also indicative. C-MET over-expression among NSCLC patients that underwent surgical resection is a prognostic factor that indicated adverse survival on OS. Whereas, p-met didn't appear to have an impact on the prognosis of NSCLC. The studies are need and the topic could be re-valued by then.
在各项研究中，已报道MET蛋白表达与非小细胞肺癌（NSCLC）患者的生存率相关，但结果并不一致。我们研究的目的是确定c-MET和p-MET表达在接受手术切除的NSCLC患者中的预后作用。通过检索PubMed、Cochrane图书馆、EMBASE和科学网，从回顾性队列研究中获取数据，并进行荟萃分析以评估MET表达在NSCLC中的预后作用。总共纳入了18篇文献，包括5572例I-IV期接受手术切除的NSCLC病例进行数据合成。c-MET和p-MET的阳性率分别为1753/4315和135/1257。c-MET和p-MET表达对总生存期（OS）的合并风险比（HR）分别为1.623（95%CI：1.176-2.240，P=0.003）和1.710（95%CI：0.823-3.533，P=0.15）。亚洲人群（HR=2.115，P<0.001）、腺癌（HR=2.220，P<0.001）和兔多克隆抗体（HR=2.107，P<0.001）等亚组分析结果也具有指示性。接受手术切除的NSCLC患者中c-MET过表达是一个预后因素，表明对OS生存不利。而p-MET似乎对NSCLC的预后没有影响。仍需要进一步研究，届时该主题可能会被重新评估。
