Department of Ophthalmology, West China Hospital, Sichuan University, Sichuan Province, Chengdu, People's Republic of China.
Department of Pathology, West China Hospital, Sichuan University, Sichuan Province, Chengdu, People's Republic of China.
Ophthalmic Plast Reconstr Surg. 2020 Jul/Aug;36(4):e84-e85. doi: 10.1097/IOP.0000000000001592.
Lymphoma is common in IgG4-related disease, but diffuse large B-cell lymphoma in IgG4-related ophthalmic disease is rare, especially involving the same organ affected by IgG4-related ophthalmic disease. The authors report a 44-year-old man presented with bilateral proptosis for 10 years and rapid loss of vision in the right eye for the last 1 month. The authors performed orbital exenteration for the right eye and resected the tumor in the left eye. Based on the clinicopathologic findings, tumors of the right and left eyes were diagnosed as diffuse large B-cell lymphoma and IgG4-related ophthalmic disease, respectively. This case highlights the risk of malignant transformation of IgG4-related ophthalmic disease.
淋巴瘤在 IgG4 相关疾病中很常见,但 IgG4 相关眼病中的弥漫性大 B 细胞淋巴瘤很少见,尤其是累及与 IgG4 相关眼病相同的器官。作者报告了一例 44 岁男性,双侧眼球突出 10 年,右眼视力在过去 1 个月迅速下降。作者对右眼进行了眼眶内容物剜除术,并对左眼肿瘤进行了切除。根据临床病理发现,右眼和左眼的肿瘤分别诊断为弥漫性大 B 细胞淋巴瘤和 IgG4 相关眼病。本病例提示 IgG4 相关眼病存在恶性转化的风险。