PSL Research University, ESPCI-Paris, Équipe de Statistique Appliquée, F-75005 Paris, France; Sorbonne Université, INSERM, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, F-75013 Paris, France.
PSL Research University, ESPCI-Paris, Équipe de Statistique Appliquée, F-75005 Paris, France; Sorbonne Université, INSERM, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, F-75013 Paris, France.
Respir Physiol Neurobiol. 2020 Apr;275:103382. doi: 10.1016/j.resp.2020.103382. Epub 2020 Jan 8.
In amphibians, there is some evidence that (1) anatomically separate brainstem respiratory oscillators are involved in rhythm generation, one for the buccal rhythm and another for the lung rhythm and (2) they become functionally coupled during metamorphosis. The present analysis, performed on neurograms recorded using brainstem preparations from Lithobates catesbeianus, aims to investigate the temporal organisation of lung and buccal burst types. Continuous Wavelet Transfom applied to the separated buccal and lung signals of a neurogram revealed that both buccal and lung frequency profiles exhibited the same low frequency peak around 1 Hz. This suggests that a common 'clock' organises both rhythms within an animal. A cross-correlation analysis applied to the buccal and lung burst signals revealed their similar intrinsic oscillation features, occurring at approximately 25 Hz. These observations suggest that a coupling between the lung and buccal oscillators emerges at metamorphosis. This coupling may be related to inter-connectivity between the two oscillators, and to a putative common drive.
在两栖动物中，有一些证据表明（1）解剖上独立的脑干呼吸振荡器参与节律产生，一个用于口部节律，另一个用于肺部节律，（2）它们在变态过程中变得功能耦合。本分析针对来自 Lithobates catesbeianus 的脑干制备物记录的神经图进行，旨在研究肺部和口部爆发类型的时间组织。应用于神经图中分离的口部和肺部信号的连续小波变换表明，口部和肺部的频率分布都在 1Hz 左右显示出相同的低频峰值。这表明一个共同的“时钟”在动物体内组织两个节律。应用于口部和肺部爆发信号的互相关分析表明，它们的内在振荡特征相似，约为 25Hz。这些观察结果表明，肺和口部振荡器之间的耦合在变态过程中出现。这种耦合可能与两个振荡器之间的互联性以及假定的共同驱动力有关。
