用于治疗肾上腺皮质功能不全的双相释放氢化可的松：一项系统评价
Dual-release hydrocortisone for treatment of adrenal insufficiency: a systematic review.
作者信息
Mongioì Laura Maria, Condorelli Rosita Angela, Barbagallo Federica, La Vignera Sandro, Calogero Aldo Eugenio
机构信息
Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.
出版信息
Endocrine. 2020 Mar;67(3):507-515. doi: 10.1007/s12020-020-02187-7. Epub 2020 Jan 11.
Dual-release hydrocortisone is a new hydrocortisone formulation developed to improve the pharmacokinetic and the pharmacodynamic profiles and patient compliance. The aim of this review is to summarize the main knowledge on dual-release hydrocortisone, with particular attention to pharmacokinetics, metabolic and health-related quality-of-life aspects, bone health and drug safety.
双相释放氢化可的松是一种新开发的氢化可的松制剂，旨在改善药代动力学和药效学特征以及患者的依从性。本综述的目的是总结关于双相释放氢化可的松的主要知识，特别关注药代动力学、代谢及与健康相关的生活质量方面、骨骼健康和药物安全性。
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