Department of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Physiol Res. 2019 Dec 20;68(Suppl 3):S361-S366. doi: 10.33549/physiolres.934347.
Mechanism of ictogenesis of D- and L-stereroisomers of homocysteic acid was studied in 12-day-old rats by means of antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. There was no qualitative difference between the two stereoisomers in generation of emprosthotonic (flexion) as well as generalized tonic-clonic seizures. Moderate differences were observed in the first, nonconvulsive effects of the two isomers. As generation of the two types of seizures is concerned, NMDA and AMPA participate in generalized tonic-clonic seizures whereas NMDA receptors play a dominant role in generation of flexion seizures.
我们采用 N-甲基-D-天冬氨酸（NMDA）和 α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体拮抗剂，研究了 D-和 L-型同型半胱氨酸立体异构体致痫的机制。两种立体异构体在引发强直-阵挛性（屈肌）和全身性强直-阵挛性癫痫方面没有质的区别。两种异构体的初次、非惊厥性作用有明显的差异。就两种类型的癫痫发作而言，NMDA 和 AMPA 参与全身性强直-阵挛性癫痫发作，而 NMDA 受体在屈肌性癫痫发作中起主导作用。
