Department of Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Physiol Res. 2019 Dec 20;68(Suppl 3):S367-S372. doi: 10.33549/physiolres.934361.
Neurostimulation methods are used in the treatment of chronic pain, although mainly for pharmacology resistant pain. Transcranial Direct Current Stimulation (tDCS) is a non-invasive neurostimulation method using low direct current (0.029-0.08 mA/cm2) applied to a cathode and anode, which directly stimulates the cranial surface. The applied current causes the most significant changes directly under the electrodes: the cathode reduces the excitability of cortical neurons, whereas the anode increases excitability. The effect of stimulation usually lasts a few hours up to a few days. We observed 19 patients with chronic orofacial pain. Inclusion criteria for the study were the following: orofacial pain, stable analgesic medication for at least one week before the beginning of stimulation and during its course, and age 18-75 years old. Patients with severe organic brain damage or seizure disease (epilepsy) were not included. The most common diagnosis was secondary trigeminal neuralgia after dental surgery. We measured thermal and tactile stimulation on the face before and after tDCS, then at 14 days. The total follow-up period lasted six months. We evaluated pain on a numerical scale (0-10) at each follow-up. We used sets of inventories focused on the examination of pain (a short form of McGill inventory), depression, anxiety, and pain interference with daily activities. tDCS is a non-invasive stimulation technique that is affordable and can be easily administered, especially when compared to other neurostimulation techniques. Only 15 patients out of the total number of 19 responded to the questionnaires.
神经刺激方法被用于治疗慢性疼痛,尽管主要是针对药理学抵抗性疼痛。经颅直流电刺激(tDCS)是一种非侵入性的神经刺激方法,使用 0.029-0.08 mA/cm2 的低直流电施加于阴极和阳极,直接刺激颅面。施加的电流会导致电极下最显著的变化:阴极降低皮质神经元的兴奋性,而阳极则增加兴奋性。刺激的效果通常持续数小时至数天。我们观察了 19 名患有慢性颌面疼痛的患者。研究纳入标准如下:颌面疼痛,在刺激开始前和刺激过程中稳定的镇痛药物至少使用一周,年龄在 18-75 岁之间。严重器质性脑损伤或癫痫疾病(癫痫)的患者不包括在内。最常见的诊断是牙科手术后的继发性三叉神经痛。我们在 tDCS 前后对面部进行了热和触觉刺激测量,然后在第 14 天测量。总的随访期持续六个月。我们在每次随访时都使用数字量表(0-10)评估疼痛。我们使用了专注于疼痛检查的问卷(麦吉尔疼痛问卷的简短形式)、抑郁、焦虑和疼痛对日常活动的干扰。tDCS 是一种非侵入性的刺激技术,价格实惠,易于管理,尤其是与其他神经刺激技术相比。在总共 19 名患者中,只有 15 名患者对问卷做出了回应。