Jenei Alex, Hes Ondrej, Kuthi Levente
Patológiai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Állomás u 1., 6725.
Charles University Hospital Plzeň.
Orv Hetil. 2020 Jan;161(3):83-94. doi: 10.1556/650.2020.31654.
Renal cell carcinoma (RCC) represents a heterogenous group of malignant tumors that originate from the kidney parenchyma. The different entities have their own specific epidemiological, morphological, immunohistochemical, genetic and clinical characteristics. The new WHO classification of renal tumors was published in 2016, and it takes all of these features together into account. Although in the past three years, several emerging subtypes have been described, these are not yet included in the current classification. In this review paper, these entities are summarized in details including the following emerging subsets: thyroid-like follicular carcinoma, rearrangement-associated RCC, renal cell carcinoma with prominent smooth muscle stroma, fumarate hydratase-deficient RCC, biphasic squamoid papillary RCC, eosinophilic solid and cystic RCC, atrophic kidney-like RCC, clear cell RCC with giant cells and emperipolesis, Warthin-like papillary RCC, low-grade oncocytic renal tumor (CD117-negative; CK7-positive), high-grade oncocytic renal tumor, -mutated RCC and chromophobe RCC with neuroendocrine features. These entities are mostly diagnosed as RCC unclassified. The aim of this study is to introduce these subsets to the Hungarian pathologists, oncologists and urologists, to prompt diagnostic accuracy and to facilitate a collection along with a consecutive analysis of these cases. Orv Hetil. 2020; 161(3): 83-94.
肾细胞癌（RCC）是一组起源于肾实质的异质性恶性肿瘤。不同的实体有其自身特定的流行病学、形态学、免疫组化、遗传学和临床特征。2016年发布了新的WHO肾肿瘤分类，该分类综合考虑了所有这些特征。尽管在过去三年中已经描述了几种新出现的亚型，但目前的分类中尚未包括这些亚型。在这篇综述论文中，详细总结了这些实体，包括以下新出现的亚组：甲状腺样滤泡癌、重排相关肾细胞癌、具有显著平滑肌间质的肾细胞癌、延胡索酸水合酶缺陷型肾细胞癌、双相鳞状乳头肾细胞癌、嗜酸性实性和囊性肾细胞癌、萎缩肾样肾细胞癌、具有巨细胞和血细胞吞噬现象的透明细胞肾细胞癌、沃辛样乳头状肾细胞癌、低级别嗜酸性肾肿瘤（CD117阴性；CK7阳性）、高级别嗜酸性肾肿瘤、-突变肾细胞癌和具有神经内分泌特征的嫌色肾细胞癌。这些实体大多被诊断为未分类的肾细胞癌。本研究的目的是向匈牙利病理学家、肿瘤学家和泌尿科医生介绍这些亚组，提高诊断准确性，并促进对这些病例的收集及后续分析。《匈牙利医学周报》。2020年；161(3): 83-94。
