Laryngology Study Group of Young-Otolaryngologists, International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
Department of Human Anatomy and Experimental Oncology, School of Medicine, UMONS Research Institute for Health Sciences and Technology, 54521University of Mons (UMons), Mons, Belgium.
Ear Nose Throat J. 2021 Feb;100(1_suppl):4S-13S. doi: 10.1177/0145561319899183. Epub 2020 Jan 13.
To investigate the indications, efficacy, safety, and outcomes of potassium-titanyl-phosphate (KTP) laser procedures for treatment of laryngeal disease.
PubMed, Cochrane Library, and Scopus were searched for studies providing information about the indications, efficacy, and safety of both in-office and operative suspension microlaryngoscopy KTP laser procedure in treatment of laryngeal disease. Diagnostic criteria and clinical outcome evaluation of included studies were analyzed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria.
Of the initial screened 140 papers, 17 met our inclusion criteria. Six papers involved KTP laser procedures for benign and malignant vocal fold lesions in suspension microlaryngoscopy only, 10 papers focused on only in-office KTP laser procedures for benign vocal fold lesions, and 1 paper included both in-office and suspension microlaryngoscopy procedures. The following lesions may be considered as indications for KTP laser procedures: Reinke's edema, sulcus vocalis, vocal fold hemorrhage, polyp, granuloma, cyst, scar, papillomatosis, dysplasia, leukoplakia, and early vocal fold malignancies. Irrespective of the types of procedure (in-office vs suspension microlaryngoscopy), the KTP laser is associated with a low complication rate and overall good vocal fold vibration recovery. There is an important heterogeneity among studies concerning laser settings, indications, and outcomes used for the assessment of treatment effectiveness. There are no controlled studies directly comparing KTP laser with other lasers (ie, carbon dioxide laser).
The use of KTP laser procedures for treatment of laryngeal disease has increased over the past decade, especially for office-based management of vocal fold lesions. Future controlled studies are needed to compare the safety and outcomes of the KTP laser to other techniques.
探讨钬钛酸钾（KTP）激光治疗喉部疾病的适应证、疗效、安全性和结局。
检索 PubMed、Cochrane 图书馆和 Scopus，以获取有关门诊和手术悬雍垂显微镜 KTP 激光治疗喉部疾病的适应证、疗效和安全性的研究信息。使用系统评价和荟萃分析首选报告项目（PRISMA）标准分析纳入研究的诊断标准和临床结局评估。
最初筛选出的 140 篇论文中，有 17 篇符合纳入标准。6 篇论文涉及悬雍垂显微镜下良性和恶性声带病变的 KTP 激光手术，10 篇论文仅关注门诊 KTP 激光治疗良性声带病变，1 篇论文包括门诊和悬雍垂显微镜手术。以下病变可被视为 KTP 激光手术的适应证：任克氏水肿、声带沟、声带出血、息肉、肉芽肿、囊肿、瘢痕、乳头状瘤病、发育不良、白斑病和早期声带恶性肿瘤。无论手术类型（门诊 vs 悬雍垂显微镜）如何，KTP 激光与低并发症率和整体良好的声带振动恢复相关。关于激光参数、适应证和用于评估治疗效果的结局，研究之间存在重要的异质性。目前尚无直接比较 KTP 激光与其他激光（如二氧化碳激光）的对照研究。
在过去十年中，KTP 激光治疗喉部疾病的应用有所增加，特别是用于声带病变的门诊管理。需要未来的对照研究来比较 KTP 激光与其他技术的安全性和结局。
