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病灶内注射类固醇对兔模型声带瘢痕形成有有效缓解作用吗？

Does Intralesional Steroid Injection Effectively Mitigate Vocal Fold Scarring in A Rabbit Model?

作者信息

Jeong Jun-Yeong, Thapa Samjhana, Lee Seung-Won

机构信息

Department of Otolaryngology - Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.

Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan, Korea.

出版信息

Laryngoscope. 2025 Jan;135(1):176-182. doi: 10.1002/lary.31782. Epub 2024 Oct 1.

DOI:10.1002/lary.31782
PMID:39352064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11635139/
Abstract

OBJECTIVES

To assess the efficacy of intralesional steroid treatment in preventing vocal fold scarring following vocal fold surgery using a rabbit model.

METHODS

The research involved 42 male New Zealand white rabbits. Fourteen rabbits underwent vocal fold scar surgery using a 532nm laser and served as controls (control group). The remaining rabbits were divided into two groups of 14: one group received vocal fold scar surgery followed by dexamethasone injection (Dexa group) and the other received the same surgery followed by triamcinolone injection (Triam group). Four weeks after surgery, histological examinations and high-speed video analyses of vocal fold vibration were conducted. The maximum amplitude of vibration was the primary measure for assessing vocal fold function. In addition, real-time polymerase chain reaction (PCR) studies were undertaken to analyze scar regeneration and remodeling.

RESULTS

The maximum amplitude differences were notably higher in the Dexa and Triam groups than in controls. Histologically, the collagen density (CD) ratios in both the Dexa and Triam groups were significantly reduced compared with controls. Real-time PCR analysis indicated marked elevations of Has-2 and Mmp-9 in the Dexa and Triam groups relative to controls.

CONCLUSIONS

Intralesional steroid injections after vocal fold surgery are effective for reducing vocal fold scarring in a rabbit model.

LEVEL OF EVIDENCE

NA Laryngoscope, 135:176-182, 2025.

摘要

目的

使用兔模型评估病灶内注射类固醇治疗在预防声带手术后声带瘢痕形成方面的疗效。

方法

该研究纳入42只雄性新西兰白兔。14只兔子接受532nm激光声带瘢痕手术并作为对照组（对照组）。其余兔子分为两组，每组14只：一组接受声带瘢痕手术后注射地塞米松（地塞米松组），另一组接受相同手术后注射曲安奈德（曲安奈德组）。术后4周，进行组织学检查和声带振动的高速视频分析。振动的最大幅度是评估声带功能的主要指标。此外，进行实时聚合酶链反应（PCR）研究以分析瘢痕再生和重塑。

结果

地塞米松组和曲安奈德组的最大幅度差异明显高于对照组。组织学上，地塞米松组和曲安奈德组的胶原密度（CD）比与对照组相比均显著降低。实时PCR分析表明，地塞米松组和曲安奈德组相对于对照组，Has-2和Mmp-9显著升高。

结论

声带手术后病灶内注射类固醇对减少兔模型中的声带瘢痕形成有效。

证据水平

NA《喉镜》，135:176 - 182，2025年。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/0d50995600b2/LARY-135-176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/8e7276c70d75/LARY-135-176-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/ea58f591dec5/LARY-135-176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/d8cc0e82e58e/LARY-135-176-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/193fa4dc3f3c/LARY-135-176-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/0d50995600b2/LARY-135-176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/8e7276c70d75/LARY-135-176-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/ea58f591dec5/LARY-135-176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/d8cc0e82e58e/LARY-135-176-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/193fa4dc3f3c/LARY-135-176-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685b/11635139/0d50995600b2/LARY-135-176-g001.jpg

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J Voice. 2023 Oct 28. doi: 10.1016/j.jvoice.2023.09.004.
2
A Novel Intervention That Prevents Vocal Fold Scarring.一种预防声带瘢痕形成的新型干预措施。
J Voice. 2023 Oct 6. doi: 10.1016/j.jvoice.2023.08.009.
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Comparison of therapeutic effects of steroid injection by benign vocal fold lesion type.不同类型声带良性病变的激素注射治疗效果比较。
Acta Otolaryngol. 2021 Nov;141(11):1005-1013. doi: 10.1080/00016489.2021.1995895. Epub 2021 Nov 9.
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Volumetric Analysis of the Vocal Folds Using Computed Tomography: Effects of Age, Height, and Gender.使用计算机断层扫描对声带进行容积分析：年龄、身高和性别影响。
Laryngoscope. 2021 Jan;131(1):E240-E247. doi: 10.1002/lary.28750. Epub 2020 Jun 17.
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A 532-nm KTP Laser for Vocal Fold Polyps: Efficacy and Relative Factors.532nm KTP 激光治疗声带息肉：疗效及相关因素。
Ear Nose Throat J. 2021 Feb;100(1_suppl):87S-93S. doi: 10.1177/0145561320946153. Epub 2020 Aug 10.
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The Use of 532-Nanometer-Pulsed Potassium-Titanyl-Phosphate (KTP) Laser in Laryngology: A Systematic Review of Current Indications, Safety, and Voice Outcomes.532 纳米脉冲钾钛磷酸盐（KTP）激光在喉科学中的应用：当前适应证、安全性和嗓音结局的系统评价。
Ear Nose Throat J. 2021 Feb;100(1_suppl):4S-13S. doi: 10.1177/0145561319899183. Epub 2020 Jan 13.
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Volumetric analysis of vocal fold atrophy via magnetic resonance imaging.通过磁共振成像对声带萎缩进行容积分析。
J Laryngol Otol. 2018 Sep;132(9):822-826. doi: 10.1017/S0022215118001573. Epub 2018 Sep 13.
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