催化臭氧化磺胺嘧啶：反应动力学和转化机制。
Catalytic ozonation of the antibiotic sulfadiazine: Reaction kinetics and transformation mechanisms.
机构信息
Laboratory of Organic Chemistry, Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Turku, Finland.
Laboratory of Industrial Chemistry and Reaction Engineering, Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Turku, Finland.
出版信息
Chemosphere. 2020 May;247:125853. doi: 10.1016/j.chemosphere.2020.125853. Epub 2020 Jan 6.
In this work, ozone has been used to study the transformation of the antibiotic sulfadiazine (SDZ). SDZ and its transformation products was investigated using liquid chromatography coupled to mass spectrometry and using NMR. The results revealed that 6% of SDZ is transformed into 2-aminopyrimidine. A significant amount of SDZ undergoes a rearrangement reaction followed by ring-closing reactions. One of these products, SDZ-P15, is the main product after 240 min of ozonation. Almost 30% of SDZ transforms into SDZ-P15. SDZ was also transformed via the addition of one or more hydroxyl groups, via the oxidation of an amine group to a nitro group as well as via a bond cleavage reaction. Most of the intermediate products presented in this study have not previously been reported as SDZ transformation products formed using ozonation technology.
在这项工作中，臭氧被用于研究抗生素磺胺嘧啶（SDZ）的转化。使用液相色谱-质谱联用技术和 NMR 对 SDZ 及其转化产物进行了研究。结果表明，6%的 SDZ 转化为 2-氨基嘧啶。大量的 SDZ 经历了重排反应，随后发生环化反应。其中一种产物 SDZ-P15 是臭氧氧化 240 分钟后的主要产物。几乎 30%的 SDZ 转化为 SDZ-P15。SDZ 还通过添加一个或多个羟基、通过将一个胺基氧化成硝基以及通过键断裂反应进行转化。本研究中出现的大多数中间产物以前没有报道过，它们是使用臭氧氧化技术形成的 SDZ 转化产物。
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