Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China.
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Stem Cell Res. 2020 Mar;43:101699. doi: 10.1016/j.scr.2020.101699. Epub 2020 Jan 7.
Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vivo.
肥厚型心肌病（HCM）是最常见的单基因心血管疾病。在这项研究中，我们从一位 HCM 患者的皮肤成纤维细胞中生成了携带 MYH7 p. R663H（c.1988 G > A）突变的人诱导多能干细胞（iPSC）ZZUNEUi007-A。该生成的 hiPSC 系具有正常核型，强力表达多能性标记物，并能在体内分化为所有三个胚层。
Zotero 插件