Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People's Republic of China.
Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People's Republic of China; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, People's Republic of China.
Stem Cell Res. 2021 May;53:102262. doi: 10.1016/j.scr.2021.102262. Epub 2021 Feb 18.
HCM is one of the most common inheritable cardiac disease. In our study, we established a human-induced pluripotent stem cells (hiPSCs) line (ZZUNEUi016-A) from a hypertrophic cardiomyopathy patient with the pathogenic heterozygote mutation in MYH7 gene. ZZUNEUi016-A expressed pluripotency markers with normal karyotype and showed the ability to differentiate into all three germ layers in vitro.
HCM 是最常见的遗传性心脏病之一。在我们的研究中，我们从一名患有 MYH7 基因突变的肥厚型心肌病患者中建立了一个人诱导多能干细胞（hiPSC）系（ZZUNEUi016-A）。ZZUNEUi016-A 表达多能性标志物，具有正常核型，并显示出在体外分化为三个胚层的能力。
