盐酸米诺环素-依地酸-乙醇抗菌导管封管液在清除耳念珠菌生物膜方面非常有效。
Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution Is Highly Effective for Eradication of Candida auris Biofilms.
机构信息
Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.02146-19.
Abstract
is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions for the eradication of biofilms of 10 strains. MEE fully eradicated all biofilms, while taurolidine lock partially eradicated all of the biofilms. The superiority was significant for all strains tested ( = 0.002).
摘要
是一种新兴的病原体，可导致致命的中心静脉相关血流感染。通过消除生物膜来进行导管补救是一种理想的治疗选择。我们比较了牛磺罗定和米诺环素-EDTA-乙醇（MEE）导管封管液对 10 株菌生物膜的清除作用。MEE 完全清除了所有生物膜，而牛磺罗定封管液部分清除了所有生物膜。所有测试菌株的优势均具有统计学意义（=0.002）。
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