Public Health England, United Kingdom
Barts Health NHS Trust, London, United Kingdom.
Clin Microbiol Rev. 2017 Nov 15;31(1). doi: 10.1128/CMR.00029-17. Print 2018 Jan.
The emerging pathogen has been associated with nosocomial outbreaks on five continents. Genetic analysis indicates the simultaneous emergence of separate clades of this organism in different geographical locations. Invasive infection and colonization have been detected predominantly in patients in high-dependency settings and have garnered attention due to variable antifungal resistance profiles and transmission within units instituting a range of infection prevention and control measures. Issues with the identification of using both phenotypic and molecular techniques have raised concerns about detecting the true scale of the problem. This review considers the literature available on and highlights the key unknowns, which will provide direction for further work in this field.
这种新出现的病原体与五大洲的医院感染爆发有关。基因分析表明,该病原体在不同地理位置的单独分支同时出现。侵袭性感染和定植主要发生在高依赖环境的患者中,由于抗真菌耐药谱的变化以及在实施各种感染预防和控制措施的单位内传播,引起了人们的关注。使用表型和分子技术鉴定 时存在的问题引起了人们对检测问题真实规模的关注。本综述考虑了有关 的现有文献,并强调了关键的未知因素,这将为该领域的进一步工作提供方向。