Armbrecht H J, Strong R, Boltz M, Rocco D, Wood W G, Richardson A
Education and Clinical Center, Veterans Administration Medical Center, St. Louis, MO 63125.
J Nutr. 1988 Nov;118(11):1360-5. doi: 10.1093/jn/118.11.1360.
The purpose of this study was to determine the effect of food restriction on age-related changes in serum 1,25-dihydroxyvitamin D and PTH, two important regulators of Ca metabolism. Starting at 6 wk, male F344 rats were fed a purified diet either ad libitum (non-restricted) or 60% of ad libitum (restricted). Rats from each group were killed at 5, 13, 22 and 28 mo of age. Dietary restriction increased the median lifespan from 24 to 31 mo. It delayed the rapid decrease in serum 1,25-dihydroxyvitamin D from 1.5-5.0 mo in the non-restricted group to 5-13 mo in the restricted group. It also completely suppressed the marked rise in serum PTH which occurred at 22 and 28 mo in the non-restricted group. Dietary restriction had these effects even though both groups of animals consumed the same amount of Ca per gram body weight. Diet had no effect on serum Ca and P, except at 28 mo. These effects of dietary restriction on serum 1,25-dihydroxyvitamin D and PTH may result in altered Ca metabolism in dietary restricted F344 rats.
本研究的目的是确定食物限制对血清1,25 - 二羟维生素D和甲状旁腺激素（Ca代谢的两个重要调节因子）与年龄相关变化的影响。从6周龄开始，雄性F344大鼠被喂食纯化饮食，一组随意进食（非限制组），另一组进食量为随意进食量的60%（限制组）。每组大鼠在5、13、22和28月龄时处死。饮食限制使中位寿命从24个月延长至31个月。它将血清1,25 - 二羟维生素D的快速下降从非限制组的1.5 - 5.0个月延迟至限制组的5 - 13个月。它还完全抑制了非限制组在22和28月龄时血清甲状旁腺激素的显著升高。尽管两组动物每克体重摄入的Ca量相同，但饮食限制仍产生了这些影响。饮食对血清Ca和P没有影响，除了在28月龄时。饮食限制对血清1,25 - 二羟维生素D和甲状旁腺激素的这些影响可能导致饮食限制的F344大鼠的Ca代谢发生改变。
