脑脊液中的胆红素：窒息大鼠血脑屏障破坏的一个指标
Bilirubin in cerebrospinal fluid: an indicator of blood-brain barrier disruption in asphyxiated rats.
作者信息
Shukla H, Atakent Y S, Ferrara A, Pincus M, Greco A
机构信息
Department of Pediatrics, New York University Medical Center, NY 10016.
出版信息
J Perinatol. 1988 Spring;8(2):118-21.
To evaluate the relationship of serum cerebrospinal fluid (CSF) and brain total bilirubin levels in asphyxia, an experiment was designed with 5 to 6-week-old Sprague-Dawley rats. The rats were randomized into control and experimental groups. All rats received intravenously 30 mg/kg of bilirubin. Four hours later the experimental group was asphyxiated. Forty-eight hours after asphyxiation, the bilirubin concentrations in blood, CSF, and brain were measured in both study groups. Mean CSF and brain bilirubin levels were significantly higher in the experimental compared to the control group; however, mean serum bilirubin levels were not different. Moreover, in the experimental group a significant correlation existed between CSF and brain bilirubin concentrations. In conclusion, an asphyxiatic insult resulted in disruption of both the blood-brain and the blood-CSF barriers.
为评估窒息时血清、脑脊液（CSF）和脑总胆红素水平之间的关系，设计了一项实验，选用5至6周龄的斯普拉格-道利大鼠。将大鼠随机分为对照组和实验组。所有大鼠静脉注射30mg/kg胆红素。4小时后，实验组进行窒息处理。窒息48小时后，测量两个研究组血液、脑脊液和脑内的胆红素浓度。与对照组相比，实验组脑脊液和脑胆红素平均水平显著更高；然而，血清胆红素平均水平并无差异。此外，在实验组中，脑脊液和脑胆红素浓度之间存在显著相关性。总之，窒息性损伤导致血脑屏障和血脑脊液屏障均被破坏。
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