局部热刺激对血氧饱和度与速度分辨血流灌注相关性的影响。
Impact of local thermal stimulation on the correlation between oxygen saturation and speed-resolved blood perfusion.
机构信息
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Acupuncture and Tuina School, Hunan University of Chinese Medicine, Changsha, China.
出版信息
Sci Rep. 2020 Jan 13;10(1):183. doi: 10.1038/s41598-019-57067-6.
The physiologically important relationship between oxygen saturation and blood flow is not entirely understood, particularly with regard to the multiple velocity components of flow and temperature. While our previous studies used classic laser Doppler flowmetry combined with an enhanced perfusion probe to assess local blood flow following thermal stimulation, oxygen saturation signals were not assessed. Thus, the current study used multiscale entropy (MSE) and multiscale fuzzy entropy (MFE) to measure the complexity of oxygen saturation signals following thermal stimulation in healthy subjects. The results indicate that thermal stimulation increases oxygen saturation and affects the measured signal complexity in a temperature-dependent fashion. Furthermore, stimulus temperature not only affects the correlation between speed-resolved blood perfusion and oxygen saturation, but also the correlation between the complexity area indices (CAI) of the two signals. These results reflect the complexity of local regulation and adaptation processes in response to stimuli at different temperatures.
氧饱和度与血流之间的生理重要关系尚未完全阐明，特别是对于血流的多个速度分量和温度。虽然我们之前的研究使用经典的激光多普勒流量测量法结合增强型灌注探头来评估热刺激后的局部血流，但并未评估氧饱和度信号。因此，本研究使用多尺度熵（MSE）和多尺度模糊熵（MFE）来测量健康受试者热刺激后氧饱和度信号的复杂性。结果表明，热刺激会增加氧饱和度，并以温度依赖的方式影响测量信号的复杂性。此外，刺激温度不仅会影响速度分辨血流与氧饱和度之间的相关性，还会影响两个信号的复杂度面积指数（CAI）之间的相关性。这些结果反映了局部调节和适应过程对不同温度刺激的复杂性。
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