Yu Guohua, Yang Ping, Ran Wenwen, Xing Xiaoming, Wang Ting, Wu Shishou, Pan Xubo, Qu Guimei, Gai Pengzhou, Ding Weifang
Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University Yantai, China.
Department of Pathology, Affiliated Hospital, Qingdao University Qingdao, China.
Int J Clin Exp Pathol. 2019 May 1;12(5):1642-1648. eCollection 2019.
To explore the pathologic features of gastric chondroid gastrointestinal stromal tumors.
The clinicopathologic data of one case of gastric chondroid gastrointestinal stromal tumor were collected and the features were analyzed by literature review.
The male patient was 64 years old and had suffered from upper abdominal fullness discomfort without obvious cause for 5 years. Gastroscopic examination showed a rough area located in the lesser curvature of the gastric antrum, measuring 6 cm × 4 cm. CT scan showed the stomach wall was unevenly thick at the gastric antrum and stomach outlet. Multiple enlarged lymph nodes were seen nearby. The biopsy pathology showed adenocarcinoma of gastric antrum. The patient underwent laparoscopic gastrectomy and gastric chondroid gastrointestinal stromal tumor was found with adenocarcinoma of the stomach. Asp842Val mutation was found in the PDGFRα 18 exon.
Gastric chondroid gastrointestinal stromal tumors are rare and low risk. Tumor cells express CD117 and Asp842Val mutation in the PDGFRα 18 exon revealed by genetic sequencing suggesting this kind of tumor might be resistant to imatinib.
探讨胃软骨样胃肠道间质瘤的病理特征。
收集1例胃软骨样胃肠道间质瘤的临床病理资料，并结合文献复习分析其特点。
该男性患者64岁，无明显诱因上腹部饱胀不适5年。胃镜检查显示胃窦小弯侧有一粗糙区域，大小为6 cm×4 cm。CT扫描显示胃窦及胃出口处胃壁不均匀增厚，附近可见多个肿大淋巴结。活检病理显示胃窦腺癌。患者接受腹腔镜胃切除术，术中发现胃软骨样胃肠道间质瘤合并胃癌。基因测序显示PDGFRα第18外显子存在Asp842Val突变。
胃软骨样胃肠道间质瘤罕见且风险低。肿瘤细胞表达CD117，基因测序显示PDGFRα第18外显子存在Asp842Val突变，提示此类肿瘤可能对伊马替尼耐药。
