Cardiology Department, Adıyaman University Training and Research Hospital, 02000 Adıyaman, Turkey.
Cardiology Department, Bayrampasa Kolan Hospital, 34000 İstanbul, Turkey.
Medicina (Kaunas). 2020 Jan 6;56(1):20. doi: 10.3390/medicina56010020.
Epilepsy patients have a higher risk of sudden unexplained death compared to the rest of the population. Cardiac repolarization abnormalities might be seen in epilepsy during interictal periods. We aimed to evaluate the changes in electrocardiography (ECG) parameters in generalized tonic-clonic seizure patients treated with carbamazepine or valproic acid (VPA) drug.
A totally of 129 subjects (66 epilepsy patients, 63 healthy subjects) were enrolled in the study. Of the patients, 36 were on carbamazepine and 30 were on VPA. There were 12-lead ECGs obtained from all participants. RR interval (time between consecutive R peaks), QT interval (defines the period of ventricular repolarization), corrected QT (QT interval corrected for heart rate; QTc), QTc-maximum (QTc-max), QTc-minimum (QTc-min), QTc dispersion (QTcd), P (atrial depolarization )-maximum (P-max), P-minimum (P-min) and P dispersion (Pd) were measured.
QTd (QT dispersion), QTcd, and Pd values were significantly higher in the patients compared to the controls ( < 0.01). QTcd, Pd, and P-max values were statistically higher in male patients compared to healthy male controls. QTcd values were significantly higher in female patients using carbamazepine compared to the female patients on VPA and healthy controls ( = 0.01). Male patients using VPA had significantly higher QTcd values against the male population in carbamazepine and control groups.
This study demonstrated that QTd, QTcd, and Pd values were significantly higher in epilepsy patients than in healthy controls. In addition, female patients using carbamazepine and male patients using VPA were prone to ventricular arrhythmia compared to the control group.
与普通人群相比，癫痫患者突发不明原因死亡的风险更高。癫痫患者在发作间期可能出现心脏复极异常。我们旨在评估卡马西平或丙戊酸（VPA）药物治疗的全面强直阵挛性癫痫发作患者的心电图（ECG）参数变化。
本研究共纳入 129 名受试者（66 名癫痫患者，63 名健康对照者）。其中 36 名患者服用卡马西平，30 名患者服用 VPA。所有参与者均进行 12 导联心电图检查。测量 RR 间期（连续 R 波峰之间的时间）、QT 间期（心室复极时间）、校正 QT（心率校正的 QT 间期；QTc）、QTc-最大（QTc-max）、QTc-最小（QTc-min）、QTc 离散度（QTcd）、P 波（心房去极化）-最大（P-max）、P 波最小（P-min）和 P 波离散度（Pd）。
与对照组相比，患者的 QTd（QT 离散度）、QTcd 和 Pd 值显著升高（<0.01）。与健康男性对照组相比，男性患者的 QTcd、Pd 和 P-max 值更高。与 VPA 组和健康对照组的女性患者相比，服用卡马西平的女性患者的 QTcd 值明显更高（=0.01）。与卡马西平组和对照组的男性人群相比，使用 VPA 的男性患者的 QTcd 值明显更高。
本研究表明，与健康对照组相比，癫痫患者的 QTd、QTcd 和 Pd 值明显更高。此外，与对照组相比，服用卡马西平的女性患者和服用 VPA 的男性患者更容易发生室性心律失常。
