Laboratorio de Medicina Genómica del Hospital Regional Lic. Adolfo López Mateos, ISSSTE, Ciudad de México 01030, Mexico.
Integrigen de Mexico SAPI de CV. Patriotismo 12, Ciudad de México 06100, Mexico.
Int J Mol Sci. 2020 Jan 7;21(2):374. doi: 10.3390/ijms21020374.
In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern ( = 369) and Central Mexico ( = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (/rs543874, /rs12429545/rs9568856, /rs9939609, /rs6567160, /rs13130484, /rs7132908, /rs944990, /rs3829849, /rs13387838, /rs9299) were associated with BMI and seven (/rs543874, /rs12429545/rs9568856, /rs9939609, /rs6567160, rs13130484, /rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, = 0.2 × 10) and at lower AMA (β = -0.05, = 6.8 × 10). The GRS interacts with AMA to increase BMI (β = 0.03, = 6.08 × 10). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children.
在墨西哥，儿童肥胖的遗传机制知之甚少。我们评估了已知与欧洲儿童体重指数（BMI）相关的基因座在来自不同种族的墨西哥儿童中的作用。我们在来自墨西哥北部（= 369）和中部（= 8545）的梅斯蒂索人和美洲原住民（Seris、Yaquis 和纳瓦特尔语）中分别进行了 BMI 和肥胖的线性和逻辑分析。我们使用线性模型来了解美洲原住民血统（AMA）程度和遗传风险评分（GRS）对 BMI z 分数的影响。来自墨西哥北部的梅斯蒂索人超重肥胖的患病率最高（47.4%），其次是 Seri（36.2%）和中部（31.5%）的儿童。有 11 个基因座（/rs543874、/rs12429545/rs9568856、/rs9939609、/rs6567160、/rs13130484、/rs7132908、/rs944990、/rs3829849、/rs13387838、/rs9299）与 BMI 相关，7 个基因座（/rs543874、/rs12429545/rs9568856、/rs9939609、/rs6567160、rs13130484、/rs3829849）与中部墨西哥儿童的肥胖有关。一个 SNP 与北部墨西哥人和 Yaquis 的肥胖有关（/rs543874）。我们发现，GRS 越高（β=0.11，=0.2×10）和 AMA 越低（β=-0.05，=6.8×10），BMI z 分数越高。GRS 与 AMA 相互作用，增加 BMI（β=0.03，=6.08×10）。高遗传 BMI 易感性增加了 BMI 较高的风险，包括美洲原住民儿童。
