Mo Joshua H, Tan Donald, Zhao Xiaohui S, Tjoa Tjoson, Wang Beverly Y
Department of Pathology and Laboratory Medicine, UC Irvine School of Medicine, Irvine, CA 92617, USA.
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA 92697, USA.
Diagnostics (Basel). 2020 Jan 8;10(1):29. doi: 10.3390/diagnostics10010029.
Anaplastic (undifferentiated) thyroid carcinoma (ATC) is a rare malignancy which may arise from transformation of a pre-existing differentiated carcinoma. We report the unique case where a lesion of thyroid origin presented with the histological features of mature plasma cells. Immunohistochemistry confirmed the lesion to be an anaplastic thyroid carcinoma arising from papillary thyroid carcinoma. A tumor mimicking a malignancy of a different cellular origin can lead clinicians to incorrect treatment approaches. Careful correlation with clinical details and knowledge of these unique presentations is important for reaching the correct diagnosis.
间变性（未分化）甲状腺癌（ATC）是一种罕见的恶性肿瘤，可能由先前存在的分化型癌转变而来。我们报告了一例独特的病例，甲状腺来源的病变呈现出成熟浆细胞的组织学特征。免疫组化证实该病变是起源于乳头状甲状腺癌的间变性甲状腺癌。一种模仿不同细胞起源恶性肿瘤的肿瘤可能会导致临床医生采取错误的治疗方法。仔细结合临床细节并了解这些独特表现对于做出正确诊断很重要。
