PARP6在胃癌中作为一种癌基因发挥作用，并正向调控Survivin。
PARP6 acts as an oncogene and positively regulates Survivin in gastric cancer.
作者信息
Sun Xiying, Zhang Yun, Chu Mingliang, Wang Lixin, Shen Hede, Zhang Zhuxue, Hu Jianjun, Yi Wei, Yang Wenxiu, Ma Xiaobo
机构信息
Department of Pathology, The Affiliated People's Hospital of Guizhou Medical University Guiyang, China.
Central Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang, China.
出版信息
Int J Clin Exp Pathol. 2018 May 1;11(5):2364-2371. eCollection 2018.
Abstract
Poly (ADP-ribose) polymerases 6 (PARP6) is a novel member of the PARP family. Previous studies focused mostly on the role of PARP6 in colorectal cancer; however, the role of PARP6 in gastric cancer is currently unclear. In the present study, we found a high-level expression of PARP6 in gastric cancer cells and PARP6 promoted cell proliferation, migration and invasion. Moreover, we found a positive correlation exists between PARP6 and Survivin, which contributes to tumor ongoing survival. In sum, our data suggest that PARP6 may contribute to gastric cancer progression by activating the Survivin pathway.
摘要
聚（ADP-核糖）聚合酶6（PARP6）是PARP家族的一个新成员。以往的研究主要集中在PARP6在结直肠癌中的作用；然而，PARP6在胃癌中的作用目前尚不清楚。在本研究中，我们发现PARP6在胃癌细胞中高表达，且PARP6促进细胞增殖、迁移和侵袭。此外，我们发现PARP6与生存素之间存在正相关，这有助于肿瘤的持续存活。总之，我们的数据表明PARP6可能通过激活生存素途径促进胃癌进展。
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