Cytology Center, The Kanagawa Health Service Association, 58 Nihon-Ohdori Naka-ku, Yokohama-shi, Kanagawa, 231-0021, Japan.
Department of Cancer Detection for Females, The Kanagawa Health Service Association, 58 Nihon-Ohdori Naka-ku, Yokohama-shi, Kanagawa, 231-0021, Japan.
Hum Cell. 2020 Apr;33(2):397-404. doi: 10.1007/s13577-019-00307-8. Epub 2020 Jan 14.
The objective of the study was to realize whether specific signatures for high-risk human papilloma virus (HPV) infection exist in the cytologic specimens with ASC-US judgement or not. The materials are 132 cytologic specimens with the diagnosis of ASC-US, including 56 cases with positive and 76 cases with negative HPV infection. Cytological findings are compared between two groups. Immature squamous metaplastic cells with nuclear atypia, SFT/IMT dyskaryotic cells, atypical parakeratosis, smudgy nuclei and multinucleated cells are the signature of high-risk HPV infection, whereas in the HPV(-) group immature metaplastic cells without atypia, moderately mature metaplastic cells without nuclear atypia and atrophic background are more popular. Instead, there are no differences on SFT/IMT background, microorganism infection and koilocytosis with or without nuclear atypia in both groups. The specific findings to confirm high-risk HPV infection are realized and the present results will contribute to decrease an unnecessary ASC-US judgement.
本研究旨在探讨 ASC-US 细胞学诊断标本中是否存在高危型人乳头瘤病毒（HPV）感染的特异性特征。本研究共纳入 132 例 ASC-US 细胞学诊断标本，其中 HPV 感染阳性 56 例，HPV 感染阴性 76 例。对两组患者的细胞学结果进行比较。高危型 HPV 感染的特征性表现为核异型不成熟鳞状上皮化生细胞、SFT/IMT 不典型细胞、非典型角化不良、核模糊及多核细胞；而 HPV（-）组中核异型不成熟化生细胞、无核异型的中度成熟化生细胞及萎缩背景更为常见。两组间 SFT/IMT 背景、微生物感染及无异型核的挖空细胞无差异。本研究明确了诊断高危型 HPV 感染的特异性表现，有助于减少不必要的 ASC-US 诊断。
