Haidari Wasim, Strowd Lindsay C
Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Cutis. 2019 Dec;104(6):326-330;E3.
Leukemia cutis (LC) is a rare condition that results from infiltration of neoplastic cells into the skin in patients with leukemia, mainly described in case reports or small case series. This study aimed to characterize the clinical presentation of LC and its association with leukemia evolution and prognosis. A single-institution retrospective review of medical records of patients with LC was performed. Biopsy-proven LC cases diagnosed in patients with leukemia were analyzed for a variety of clinical characteristics and prognosis; 46 patients met inclusion criteria. Leukemia cutis most commonly presented in patients with acute myeloid leukemia (AML), though lesions were seen in several other leukemia types. Most LC lesions were identified at initial presentation of underlying leukemia but also occurred with leukemia relapse and at other stages of treatment. Most patients died within 1 year of LC diagnosis. The clinical presentation of LC is highly variable. Lesions occur in different anatomic regions; can present as papules, nodules, or plaques; and have different associated colors and symptoms. Duration between diagnosis of leukemia and death in patients who develop LC, and between LC diagnosis and death, are highly variable. Early detection of lesions might help provide a diagnosis in patients with leukemia and potentially improve prognosis if doing so results in earlier initiation of chemotherapy.
皮肤白血病（LC）是一种罕见病症，由白血病患者的肿瘤细胞浸润皮肤所致，主要在病例报告或小型病例系列中有所描述。本研究旨在描述皮肤白血病的临床表现及其与白血病进展和预后的关联。对一家机构中皮肤白血病患者的病历进行了回顾性研究。对经活检证实的白血病患者的皮肤白血病病例进行了多种临床特征和预后分析；46例患者符合纳入标准。皮肤白血病最常见于急性髓系白血病（AML）患者，不过在其他几种白血病类型中也可见到病变。大多数皮肤白血病病变是在潜在白血病初次出现时发现的，但也会在白血病复发时以及治疗的其他阶段出现。大多数患者在皮肤白血病诊断后1年内死亡。皮肤白血病的临床表现高度多变。病变出现在不同的解剖区域；可表现为丘疹、结节或斑块；且具有不同的相关颜色和症状。发生皮肤白血病的患者从白血病诊断到死亡的时间，以及从皮肤白血病诊断到死亡的时间，差异很大。病变的早期检测可能有助于白血病患者的诊断，并且如果这样做能导致更早开始化疗，则可能改善预后。
