131-I 放射性碘治疗格雷夫斯病、单结节性甲状腺肿和多结节性甲状腺肿患者的甲状腺功能亢进症。

131-I radioiodine therapy for hyperthyroidism in patients with Graves' disease, uninodular goitre and multinodular goitre.

作者信息

Danaci M, Feek C M, Notghi A, Merrick M V, Padfield P L, Edwards C R

机构信息

Department of Medicine, Western General Hospital, Edinburgh, Scotland.

出版信息

N Z Med J. 1988 Nov 23;101(858):784-6.

PMID:3194075

Abstract

We studied 201 consecutive patients who received a relatively fixed dose of radioiodine for the treatment of hyperthyroidism between the years 1981-6. Patients with Graves' disease (170) were initially treated with a mean (SE) dose of 369 (10) MBq 131-I with a remission rate of 94% at 6 months and a cumulative relapse rate of 12% at one year and 21% at 5 years. The cumulative incidence of hypothyroidism was 26% at 3 months, 55% at 6 months, 61% at 1 year and 66% at 5 years. Patients with a uninodular goitre (10) were initially treated with a mean (SE) dose of 438 (85) MBq 131-I with a remission rate of 100% at 6 months, without relapse at 1 year but relapsing in 17% at 5 years. The cumulative incidence of hypothyroidism was 26% at 3 months, 30% at 6 months, 40% at 1 year and 40% at 5 years. Patients with a multinodular goitre (21) were initially treated with a mean (SE) dose of 613 (77) MBq 131-I with a remission rate of 79% at 6 months and a cumulative relapse rate of 26% at 1 year and 39% at 5 years. The cumulative incidence of hypothyroidism was 5% at 3 months, 14% at 6 months, 24% at 1 year and 24% at 5 years.

摘要

我们研究了1981年至1986年间接受相对固定剂量放射性碘治疗甲状腺功能亢进症的201例连续患者。格雷夫斯病患者（170例）最初接受的131-I平均（标准误）剂量为369（10）MBq，6个月时缓解率为94%，1年时累积复发率为12%，5年时为21%。甲状腺功能减退症的累积发生率在3个月时为26%，6个月时为55%，1年时为61%，5年时为66%。单结节性甲状腺肿患者（10例）最初接受的131-I平均（标准误）剂量为438（85）MBq，6个月时缓解率为100%，1年时无复发，但5年时复发率为17%。甲状腺功能减退症的累积发生率在3个月时为26%，6个月时为30%，1年时为40%，5年时为40%。多结节性甲状腺肿患者（21例）最初接受的131-I平均（标准误）剂量为613（77）MBq，6个月时缓解率为79%，1年时累积复发率为26%，5年时为39%。甲状腺功能减退症的累积发生率在3个月时为5%，6个月时为14%，1年时为24%，5年时为24%。