Oaku Tatsuro, Yamada Nobuhisa, Ikeda Kanami, Yamane Satoki, Takemura Keisuke, Hotta Yuma, Sekoguchi Satoru, Isozaki Yutaka, Nagao Yasuyuki, Oyamada Hirokazu
Department of Gastroenterology, Matsushita Memorial Hospital.
Nihon Shokakibyo Gakkai Zasshi. 2020;117(1):72-77. doi: 10.11405/nisshoshi.117.72.
Peripheral neuropathy reportedly develops after a long period of metronidazole administration. Here, we report a case of amoebic colitis in which peripheral neuropathy occurred approximately 24 hours after administering metronidazole. A 76-year-old man presented with mucous and bloody stool. Initially, lower gastrointestinal endoscopy and stool analysis confirmed the occurrence of amoebic colitis, and metronidazole was then intravenously administered. The following day, however, the patient experienced a diminished sensation in a glove-and-stocking distribution in his extremities, followed by bilateral burning foot pain. After the withdrawal of metronidazole, the symptoms improved and finally disappeared 3 months later.
据报道，长期服用甲硝唑后会出现周围神经病变。在此，我们报告一例阿米巴结肠炎病例，该患者在静脉注射甲硝唑约24小时后出现周围神经病变。一名76岁男性出现黏液血便。最初，通过下消化道内镜检查和粪便分析确诊为阿米巴结肠炎，随后静脉注射甲硝唑。然而，第二天患者出现四肢手套-袜套样分布的感觉减退，随后出现双侧足部灼痛。停用甲硝唑后，症状有所改善，最终在3个月后消失。
