Hursh J B, Sichak S P, Clarkson T W
Environmental Health Sciences Center, University of Rochester School of Medicine, New York 14642.
Pharmacol Toxicol. 1988 Oct;63(4):266-73. doi: 10.1111/j.1600-0773.1988.tb00952.x.
A method is described for studying the in vitro oxidation of mercury vapour by red blood cells at short times and with diminishing mercury vapour concentrations. It is found that for 40% red blood cell suspensions and 37 degrees at concentrations greater than about 6 ng mercury vapour/ml, the oxidation rate is zero order, and that at lower concentrations the rate changes to first order. The effect of temperature and of added hydrogen peroxide are studied. Results are considered in terms of the generally accepted belief that the catalase-compound I system is the main path of oxidation. If the results obtained in vitro in these experiments apply in vivo to man, it follows that inhaled mercury is carried in the blood to the brain and other organs primarily as dissolved vapour rather than as inorganic mercury ions.
本文描述了一种在短时间内、汞蒸气浓度逐渐降低的情况下，研究红细胞对汞蒸气进行体外氧化的方法。研究发现，对于40%的红细胞悬液，在37摄氏度时，当汞蒸气浓度大于约6纳克/毫升时，氧化速率为零级，而在较低浓度时，速率变为一级。研究了温度和添加过氧化氢的影响。根据普遍接受的观点，即过氧化氢酶-化合物I系统是主要的氧化途径，对结果进行了分析。如果这些实验在体外获得的结果适用于人体体内情况，那么吸入的汞在血液中主要以溶解的蒸气形式而非无机汞离子形式被输送到大脑和其他器官。
