Varlamova T M, Shchedrina R N, Mataradze G D
Probl Endokrinol (Mosk). 1988 Jul-Aug;34(4):36-40.
Altogether 70 girls of pubertal age were examined: 50 with diffuse toxic goiter and 20 with hypothyrosis. A clinical picture of "hypoestrogenism" and menstrual disturbance confirmed by the results of clinical and gynecological examination and ultrasonic investigation was noted in the patients. A significant rise of the level of gonadotropic hormones correlating with the severity of disease, and a rise of the level of testosterone-estradiol binding protein were revealed. The results of the investigation suggest that changes in the reproductive system resulting from thyroid dysfunction age determined by disturbance of different links of hormonal regulation of the hypothalamo-hypophyseal-gonadal system.
总共对70名青春期女孩进行了检查：50名患有弥漫性毒性甲状腺肿，20名患有甲状腺功能减退症。通过临床、妇科检查及超声检查结果证实，患者出现了“低雌激素血症”的临床表现及月经紊乱。发现促性腺激素水平显著升高，且与疾病严重程度相关，同时睾酮 - 雌二醇结合蛋白水平也升高。调查结果表明，甲状腺功能障碍导致的生殖系统变化取决于下丘脑 - 垂体 - 性腺系统激素调节不同环节的紊乱。
