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Katanin P80 与较大的肿瘤大小、淋巴结转移以及更晚期的 TNM 分期相关，并可预测非小细胞肺癌患者的不良预后。

Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients.

机构信息

Department of Respiratory, Renmin Hospital, Hubei University of Medicine, Shiyan, China.

Teaching and Research Division of Internal Medicine, Hubei College of Chinese Medicine, Jingzhou, China.

出版信息

J Clin Lab Anal. 2020 Apr;34(4):e23141. doi: 10.1002/jcla.23141. Epub 2020 Jan 15.

DOI:10.1002/jcla.23141
PMID:31944409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7171325/
Abstract

OBJECTIVE

The present study aimed to investigate the correlation of katanin P80 expression with clinicopathological features and survival profile in non-small-cell lung cancer (NSCLC) patients.

METHODS

Totally, 398 NSCLC patients treated by pulmonary resection were enrolled and their tumor specimens were collected to determine katanin P80 expression by immunohistochemistry (IHC) assay. Clinical data were collected at diagnosis, and survival data including disease-free survival (DFS) and overall survival (OS) were assessed after treatment.

RESULTS

There were 195 (49.0%) patients with katanin P80 high expression and 203 (51.0%) patients with katanin P80 low expression, respectively. Meanwhile, katanin P80 high expression was associated with larger tumor size (P = .001), lymph node (LYN) metastasis (P = .005), and advanced TNM stage (P = .001). As for survival data, katanin P80 high expression was correlated with reduced DFS (P < .001) and OS (P < .001). And forward stepwise multivariate Cox's regression revealed that katanin P80 high expression was an independent predictor for decreased DFS (P < .001) and OS (P < .001). Besides, further analysis indicated that DFS (P < .001) and OS (P < .001) were the shortest in patients with katanin P80 high+++ expression, followed by patients with katanin P80 high++ expression and then those with katanin P80 high + expression and katanin P80 low expression.

CONCLUSION

Katanin P80 correlates with larger tumor size, LYN metastasis, and advanced TNM stage, and serves as a potential biomarker for predicting poor survival in NSCLC patients.

摘要

目的

本研究旨在探讨卡坦in P80 表达与非小细胞肺癌（NSCLC）患者临床病理特征和生存状况的相关性。

方法

共纳入 398 例接受肺切除术治疗的 NSCLC 患者，采集其肿瘤标本，采用免疫组织化学（IHC）法检测卡坦in P80 的表达。在诊断时收集临床资料，并在治疗后评估无病生存（DFS）和总生存（OS）等生存数据。

结果

卡坦in P80 高表达者 195 例（49.0%），低表达者 203 例（51.0%）。卡坦in P80 高表达与肿瘤体积较大（P =.001）、淋巴结（LYN）转移（P =.005）和晚期 TNM 分期（P =.001）有关。生存资料显示，卡坦in P80 高表达与 DFS 降低（P <.001）和 OS 降低（P <.001）有关。向前逐步多因素 Cox 回归分析显示，卡坦in P80 高表达是 DFS 降低（P <.001）和 OS 降低（P <.001）的独立预测因子。进一步分析表明，DFS（P <.001）和 OS（P <.001）最短的是卡坦in P80 高+++表达者，其次是卡坦in P80 高++表达者，然后是卡坦in P80 高+表达者和卡坦in P80 低表达者。

结论

卡坦in P80 与肿瘤体积较大、LYN 转移和晚期 TNM 分期有关，可作为预测 NSCLC 患者不良生存的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/4fbe2102bc29/JCLA-34-e23141-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/34076a84119a/JCLA-34-e23141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/b2f190b46d15/JCLA-34-e23141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/e42bfb221b3a/JCLA-34-e23141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/4fbe2102bc29/JCLA-34-e23141-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/34076a84119a/JCLA-34-e23141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/b2f190b46d15/JCLA-34-e23141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/e42bfb221b3a/JCLA-34-e23141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb7/7171325/4fbe2102bc29/JCLA-34-e23141-g004.jpg

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