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基于大鼠免疫系统器官生化指标对来自239Pu的外照射γ射线和内照射α射线联合效应的定量评估

[Quantitative evaluation of the combined effect of external gamma radiation and internal alpha radiation from 239Pu based on biochemical indices of the organs of the rat immune system].

作者信息

Elkina N I, Lumpov A I

出版信息

Radiobiologiia. 1988 Sep-Oct;28(5):695-9.

PMID:3194501
Abstract

The combined effect of external gamma-radiation (137Cs, 103-26 mC/kg) and incorporated alpha-radiation (239Pu nitrate, 93-9.3 kBq/kg body mass) was estimated by changes in the nucleic acid metabolism and the number of cells in rat thymus, spleen and bone marrow. The data obtained were processed using a model of multiplicate action of the factors which is equivalent, in the case of low effects, to a traditional model of additive effects. The results of the combined action of the two factors may be estimated by the coefficient of the interaction and the coefficient of the enhancement of the effects.

摘要

通过大鼠胸腺、脾脏和骨髓中核酸代谢及细胞数量的变化,评估了外部γ辐射(¹³⁷Cs,103 - 26 mC/kg)与摄入的α辐射(硝酸²³⁹Pu,93 - 9.3 kBq/kg体重)的联合效应。所获数据采用多因素复合作用模型进行处理,在低效应情况下,该模型等同于传统的相加效应模型。两个因素联合作用的结果可通过相互作用系数和效应增强系数来评估。

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