[Characteristic of AMP and the effects of chemical modifications on the modulation of their antimicrobial properties].

Antibiotics have revolutionized the pharmacology market but their "golden area" passed away. The urgent need to develop new medicins with the mechanism of action different than those already used is constantly growing because of the drug-resistance of pathogenic microorganisms. The observed increasing resistance of microbes motivates scientists to design innovative strategies based on the natural peptides that exhibit antimicrobial activity. In this article we present general characterization of antimicrobial peptides and effects of chemical modifications on the modulation of their antimicrobial properties.