在去氧皮质酮盐（DOCA-盐）和戈德布拉特二肾一夹高血压发展过程中大鼠对氯化钠负荷的处理
The handling of NaCl load in rats during DOCA-salt and Goldblatt 2 kidney-1 clip hypertension development.
作者信息
Vargas F, Casanova I, Haro J M, Luna J D, García del Río C
机构信息
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Granada, Spain.
出版信息
Rev Esp Fisiol. 1988 Jun;44(2):185-90.
The handling of an intraperitoneal NaCl load (2% body weight, 0.9% NaCl) administered twice a week during DOCA-salt and Goldblatt 2K-1C hypertension development has been evaluated. An exaggerated natriuresis was observed in DS-hypertensive rats since blood pressure became higher with respect to normal (C), Doca (D) and uninephrectomized-salt (NS) rats that served as controls. However, this phenomenon was not observed in Goldblatt 2K-1C hypertensive rats (2K-1C) when compared to the response obtained in sham-operated (SO) rats. These results suggest that: 1) An increased blood pressure, per se, is not a determinating factor for exaggerated natriuresis. 2) Rise in blood pressure and exaggerated natriuresis may be related through a common mechanism in Doca-salt hypertension.
已对在去氧皮质酮-盐（DOCA-盐）高血压和戈德布拉特二肾一夹（Goldblatt 2K-1C）高血压发展过程中，每周两次给予腹腔内氯化钠负荷（2%体重，0.9%氯化钠）的处理情况进行了评估。在DOCA-盐高血压大鼠中观察到了过度利钠现象，因为与作为对照的正常（C）、去氧皮质酮（D）和单侧肾切除-盐（NS）大鼠相比，其血压更高。然而，与假手术（SO）大鼠所获得的反应相比，在Goldblatt 2K-1C高血压大鼠（2K-1C）中未观察到这种现象。这些结果表明：1）血压升高本身并非过度利钠的决定因素。2）在去氧皮质酮-盐高血压中，血压升高和过度利钠可能通过共同机制相关联。
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