Zhao Yongjian, Yu Shaohui, Tao Ben, Gao Fei
Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:7119-7122. doi: 10.1109/EMBC.2019.8856595.
Photoacoustic (PA) imaging is an emerging imaging technique that combines light illumination and ultrasound detection. Conventional design of PA probe usually combines light and sound in a straightforward way without adjustable capability. In this paper, we propose a new PA imaging system based on light-adjustable handheld probe. The proposed PA imaging system includes a control unit that can adaptively find the light illumination pattern for the PA signal generation with optimized signal-to-noise ratio (SNR). Compared with traditional design of PA probe, our proposed apparatus enables the following advantages: (1) The system can automatically find the specific position parameters of the illumination scheme, and obtain the PA signal with optimized SNR by implementing a scanning process. (2) The proposed apparatus can be fully automatic and adaptive by electronic control. By scanning the sample, it can automatically obtain the optimized light exposure position. (3) Spot size and distance are adjustable. Both simulation and experimental results demonstrate the feasibility of the proposed system to have great potential in biomedical imaging with versatile configurations.
光声（PA）成像是一种新兴的成像技术，它结合了光照射和超声检测。传统的PA探头设计通常以直接的方式将光和声音结合起来，没有可调节的功能。在本文中，我们提出了一种基于光可调手持式探头的新型PA成像系统。所提出的PA成像系统包括一个控制单元，该控制单元可以自适应地找到用于产生具有优化信噪比（SNR）的PA信号的光照模式。与传统的PA探头设计相比，我们提出的装置具有以下优点：（1）该系统可以自动找到照明方案的特定位置参数，并通过执行扫描过程获得具有优化SNR的PA信号。（2）所提出的装置可以通过电子控制实现完全自动和自适应。通过扫描样品，它可以自动获得优化的光曝光位置。（3）光斑尺寸和距离是可调节的。仿真和实验结果都证明了所提出系统在具有多种配置的生物医学成像中具有巨大潜力的可行性。
