Langenscheidt F, Kiefel V, Santoso S, Mueller-Eckhardt C
Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, FRG.
Transfusion. 1988 Nov-Dec;28(6):597-600. doi: 10.1046/j.1537-2995.1988.28689059040.x.
A 65-year-old patient with pancytopenia resulting from osteomyelosclerosis became refractory to platelet transfusions during long-time transfusion support. He developed two rare, platelet-specific antibodies (anti-PlA2 and -Baka) disguised by strong, multispecific HLA antibodies. The specificity of the platelet-specific antibodies was detected by a newly designed enzyme-linked immunosorbent assay using glycoprotein-specific monoclonal antibodies for immobilization of platelet antigens.
一名65岁因骨髓纤维化导致全血细胞减少的患者，在长期输血支持过程中对血小板输注产生了抵抗。他产生了两种罕见的血小板特异性抗体（抗-PlA2和-Baka），被强烈的多特异性HLA抗体所掩盖。通过一种新设计的酶联免疫吸附测定法检测血小板特异性抗体的特异性，该方法使用糖蛋白特异性单克隆抗体固定血小板抗原。
