Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, WB 741246, India.
Chempluschem. 2019 Jan;84(1):130-135. doi: 10.1002/cplu.201800559.
The interaction between surfactants and cyclodextrins (CDs) is well known. Studies have focused mainly on destruction of micelles with CDs to release the encapsulated drugs. However, less emphasis has been given on understanding the formation of micelles with the CD encapsulated surfactants. We have used fluorescence spectroscopy to study the impact of CDs on micelles using a fluorophore that has been tactically designed as a reporter. This molecule has a pyrene moiety on one end and a cationic head group on the other so that the orientation of the compound can be prefixed on micelle formation in aqueous environment. We have observed that the CD encapsulated surfactants can form "hydrated micelles" that allow extensive penetration of water molecules toward the core. The mechanism for such a process involves inclusion of the hydrophobic surfactant tails within the CD core and participation of these inclusion complexes in micelle formation. The process could be controlled by tuning the concentration of CD. The degree of hydration varies as the micelles get more opened up due to the residence of the CDs inside them.
表面活性剂与环糊精（CDs）之间的相互作用是众所周知的。研究主要集中在破坏 CD 包裹的胶束以释放包裹的药物上。然而，对于理解 CD 包裹的表面活性剂形成胶束的过程关注较少。我们使用荧光光谱法，使用经过策略设计的荧光团作为报告分子来研究 CD 对胶束的影响。该分子的一端具有芘部分，另一端具有阳离子头基，因此化合物的取向可以预先确定在水相环境中的胶束形成中。我们观察到，CD 包裹的表面活性剂可以形成“水合胶束”，允许水分子向核心广泛渗透。这种过程的机制涉及将疏水性表面活性剂尾部分子包埋在 CD 核内，并参与这些包合物的胶束形成。通过调节 CD 的浓度可以控制该过程。由于 CDs 存在于胶束内部，胶束的开放程度越大，水合程度也会随之变化。
