扩展可降解蛋白质组：按图索骥设计 PROTACs。
Expanding the Degradable Proteome: Designing PROTACs by the Book.
机构信息
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT 25.3, 1090 Vienna, Austria.
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT 25.3, 1090 Vienna, Austria.
出版信息
Cell Chem Biol. 2020 Jan 16;27(1):14-16. doi: 10.1016/j.chembiol.2019.12.009.
In this issue of Cell Chemical Biology, Li et al. (2020), Hsu et al. (2020), and Potjewyd et al. (2020) expand the target spectrum amenable to protein degradation by designing degraders of the cell cycle checkpoint kinase Wee1 and the polycomb repressive complex 2 (PRC2) via its regulatory EED subunit.
在本期《细胞化学生物学》中，Li 等人（2020）、Hsu 等人（2020）和 Potjewyd 等人（2020）通过设计细胞周期检查点激酶 Wee1 和多梳抑制复合物 2（PRC2）的降解剂，扩展了可进行蛋白质降解的靶标谱，该降解剂通过其调节亚基 EED 进行设计。
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