Shipley P J, Shevrin D H, Kukreja S C
Department of Medicine, University of Illinois, Chicago.
J Bone Miner Res. 1988 Oct;3(5):555-60. doi: 10.1002/jbmr.5650030512.
The present studies examined renal calcium (Ca) clearance in an animal model of malignancy-associated humoral hypercalcemia (MAHH) (a human squamous cell lung carcinoma carried in athymic mice). Three groups of animals--controls, normocalcemic tumor-bearing animals and hypercalcemic tumor-bearing animals--were studied in the basal state and during Ca infusion. Baseline Ca clearance was slightly but significantly elevated in the tumor-bearing hypercalcemic animals compared with the other two groups of animals. This clearance value was, however, inappropriately low for the serum Ca value. In the control and in the normocalcemic tumor-bearing animals, Ca clearance increased markedly during Ca infusion. This increase in renal Ca clearance was markedly blunted in the hypercalcemic animals compared with both the controls and the normocalcemic tumor-bearing animals. We conclude that increased renal Ca resorption contributes significantly to the pathogenesis of hypercalcemia of malignancy.
本研究在恶性肿瘤相关性体液性高钙血症（MAHH）动物模型（无胸腺小鼠携带的人肺鳞状细胞癌）中检测了肾钙清除率。研究了三组动物——对照组、血钙正常的荷瘤动物和高钙血症荷瘤动物——在基础状态及钙输注期间的情况。与其他两组动物相比，荷瘤高钙血症动物的基线钙清除率略有升高但具有显著差异。然而，该清除率值相对于血清钙值而言过低。在对照组和血钙正常的荷瘤动物中，钙输注期间钙清除率显著增加。与对照组和血钙正常的荷瘤动物相比，高钙血症动物的肾钙清除率增加明显减弱。我们得出结论，肾钙重吸收增加对恶性肿瘤高钙血症的发病机制有显著影响。
