免疫肿瘤学的研究进展及其对接受免疫治疗患者管理的影响
[Research evolutions in immuno-oncology and their impact on the management of patients treated with immunotherapy].
作者信息
Caux Christophe
机构信息
University of Lyon, Claude Bernard Lyon 1 university, centre Léon Bérard, Cancer research center of Lyon (CRCL), immunology department, Inserm 1052, CNRS 5286, 69008 Lyon, France; CRCL, Inserm U1052, team « Therapeutic Targeting of the Tumor Cells and Their Immune Stroma », 69008 Lyon, France.
出版信息
Bull Cancer. 2020 Jan;107(1):6-9. doi: 10.1016/j.bulcan.2020.01.002. Epub 2020 Jan 15.
In this brief note, we review the state of knowledge about biomarkers that influence the response to current immunotherapies and the impact of recent technological developments (single-cell analysis, multi-dimensional imaging) on the analysis of these biomarkers. Also, new developments and strategies around CAR-T cells and bispecific antibodies in immuno-oncology are presented.
在本简短报告中，我们回顾了关于影响当前免疫疗法反应的生物标志物的知识现状，以及近期技术发展（单细胞分析、多维成像）对这些生物标志物分析的影响。此外，还介绍了免疫肿瘤学中围绕嵌合抗原受体T细胞（CAR-T）和双特异性抗体的新进展和策略。
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